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Abstract
The intramuscular injection of the carotenoid compound, Cocetin, in rabbits fed an
atherosclerosis-producing diet, resulted in greatly reduced severity of the atherosclerosis.
In addition, serum cholesterol levels were reduced by 50%. Crocetin also causes increased
oxygen diffusion through the blood plasma. Thus, these results would appear to add
evidence that hypoxia, due to reduced diffusion of oxygen at the blood-tissue interface,
plays an important and perhaps an initiating part in the pathogenesis of atherosclerosis.
Keywords
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References
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Article info
Publication history
Received:
March 3,
1973
Identification
Copyright
© 1974 Published by Elsevier Inc.
