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Stimulation of hepatic β-hydroxy-β-methylglutaryl coenzyme a reductase activity in allylamine-fed rats

  • Gene C. Ness
    Footnotes
    Affiliations
    Lipid Metabolism Laboratory, Veterans Administration Hospital, and the Departments of Pathology and Physiological Chemistry, University of Wisconsin, Madison, Wisc. 53706 U.S.A.
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  • J.J. Lalich
    Affiliations
    Lipid Metabolism Laboratory, Veterans Administration Hospital, and the Departments of Pathology and Physiological Chemistry, University of Wisconsin, Madison, Wisc. 53706 U.S.A.
    Search for articles by this author
  • John W. Porter
    Affiliations
    Lipid Metabolism Laboratory, Veterans Administration Hospital, and the Departments of Pathology and Physiological Chemistry, University of Wisconsin, Madison, Wisc. 53706 U.S.A.
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  • Author Footnotes
    ∗ Postdoctoral fellow of the Wisconsin Heart Association.
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      Abstract

      Rats fed a diet containing 0.2% allylamine hydrochloride had a 5-fold higher level of hepatic β-hydroxy-β-methylglutaryl coenzyme A reductase activity than corresponding controls. Supplementation of the allylamine-containing diet with 10% egg yolk reduced this elevated level of reductase activity. In contrast to the marked rise in their liver enzyme activity, allylamine-fed rats had no increase in serum cholesterol levels.

      Keywords

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