The effect of massive doses of ascorbic acid and methionine on the levels of lipids and glycosaminoglycans in the aorta of weanling rats

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      The levels of the glycosaminoglycans, hyaluronic acid (HA), heparan sulphate (HS), chondroitin sulphate A (Ch S-A), chondroitin sulphate C (Ch S-C), chondroitin sulphate B (Ch S-B) and heparin (H) increased in the aorta in weanling rats fed ascorbic acid or ascorbic acid + methionine. HS and Ch S-A decreased more in animals that were fed ascorbic acid alone, while Ch S-C, Ch S-B and H increased more with ascorbic acid + methionine. The cholesterol level of the serum, liver and aorta decreased with ascorbic acid, and more so with ascorbic acid + methionine. Liver phospholipids increased, and again more so with ascorbic acid + methionine. Triglyceride in the aorta and liver considerably decreased in the animals fed ascorbic acid + methionine.


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