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On the passage-restricting role of acid mucopolysaccharides in the endothelium of pig aortas

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      Abstract

      The preferred localization of fatty streaks and spots in the thoracic pig aorta are more prone to attacks by mucolytic and proteolytic enzymes than the remainder of the inner surface of the aorta. In vitro treatment of the aorta with these enzymes causes locally at the predilection sites of fatty streaks and spots an increase in permeability of the endothelium.
      Together with the increased permeability a significant extrusion of acid mucopolysaccharides was observed. These results suggest that mucopolysaccharides could play a passage-restricting role in the aortic endothelium.

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      References

        • Malyuk W.J.
        Autoradiographic investigation of 35S-incorporation into the arterial wall of rats in post-natal autogenesis (in Russian).
        in: Proceedings of the 8th Scientific Conference on Gerontology, Morphology, Physiology and Biochemistry. Vol. 2. Pedagogika, Moscow19671971: 117-118
        • Shimamoto T.
        • Kobayaski M.
        • Numano F.
        Infiltration of γ-globulin, fibrinogen and β-lipoprotein into bloodvessel wall by atherogenic stress. Visualized by immunofluorescence.
        in: Proc. Japan Acad.48. 1972: 336
        • Kasabijan S.S.
        The histochemistry of hyaluronic acid in the aorta in atherosclerosis.
        Kardiologiya. 1964; 4: 18
        • Kasabijan S.S.
        The histochemistry of hyaluronic acid in the aorta in atherosclerosis.
        Med. Ref. Zh. 1965; 1 (Abstr. 821): 3
        • Rossi G.B.
        • Caccavole E.
        • Parazzi L.C.
        Salicylate and increased vascular permeability due to hyaluronidase.
        Nature (London). 1963; 200: 685
        • Buddecke E.
        Untersuchungen zur Struktur and Funktion anionischer Polysaccharide des Bindegewebes.
        Angew. Chem. 1963; 75: 941
        • Klynstra F.B.
        • Böttcher C.J.F.
        Mucopolysaccharides and atherosclerosis.
        Lancet. 1965; i: 167
        • Klynstra F.B.
        • Böttcher C.J.F.
        Permeability patterns in pig aorta.
        Atherosclerosis. 1970; 11: 451
        • Bitter T.
        • Muir H.
        A modified uronic acid carbazole reaction.
        Anal. Biochem. 1962; 4: 330
        • Klynstra F.B.
        • Van Der Laan J.
        • Linders H.J.
        Methods for the separation of acid mucopolysaccharides of the human aorta.
        J. Atheroscler., Res. 1967; 7: 257
        • Spiro R.G.
        Biochemistry of basement membranes.
        in: Chemistry and Molecular Biology of the Intercellular Matrix. Vol. 1. Academic Press, London, New York, N. Y1970: 511
        • Schwarz S.M.
        • Benditt E.P.
        Studies on aortic intima, Part 1 (Structure and permeability of rat thoracic aortic intima).
        Amer J. Pathol. 1972; 66: 241
        • Buddecke E.
        • Kröz
        • Lanka E.
        Chemische Zusammensetzung and makromolekulare Struktur von Chondroitinsulfat-Proteinen.
        Hoppe-Seyler's Z. Physiol. Chem. 1963; 331: 196
        • Klemer A.
        • Mempel D.
        Chemische Untersuchungen an ChondroitinschwefelsaureProtein-Komplexen normaler and sklerotischer Aorten, Teil 3.
        Z. Naturforsch. 1965; 20b: 553
        • Lieflander M.
        Some investigations concerning the presence of amino acids in highly purified hyaluronic acids.
        in: Chemistry and Molecular Biology of the Intercellular Matrix. Vol. II. Academic Press, London, New York, N. Y1970: 749
        • Pries C.
        • Aumont A.
        • Bẗtcher C.J.F.
        Analysis of phospholipids.
        Biochim. Biophys. Acta. 1966; 125: 277
        • Bell F.P.
        • Somer J.B.
        • Craig I.H.
        • Schwarz C.J.
        Patterns of aortic Evans blue uptake in vivo and in vitro.
        Atherosclerosis. 1972; 16: 369
        • Lehninger A.L.
        Cell coats and ground-substance in animal tissues.
        in: Lehninger A.L. Biochemistry. Worth Publishers Inc, New York1970: 235
        • Derobertis E.D.P.
        • Nowinsky W.W.
        • Saez F.A.
        Extraneous coats of the cell membrane.
        in: De Robertis E.D.P. Nowinsky W.W. Saez F.A. Cell Biology. Saunders Co, Philadelphia, London, Toronto1970: 165
        • Revel J.P.
        • Goodenough
        Cell coats and intercellular matris.
        in: Chemistry and Molecular Biology of the Intercellular Matrix. Vol. III. Academic Press, London, New York, N. Y1970: 1361
        • Buonassisi V.
        Sulfated mucopolysaccharide synthesis and secretion in endothelial cell cultures.
        Exp. Cell Res. 1973; 76: 363
        • Simkin P.A.
        Permeability of aortic endothelium.
        Lancet. 1972; i: 793