On the passage-restricting role of acid mucopolysaccharides in the endothelium of pig aortas

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      The preferred localization of fatty streaks and spots in the thoracic pig aorta are more prone to attacks by mucolytic and proteolytic enzymes than the remainder of the inner surface of the aorta. In vitro treatment of the aorta with these enzymes causes locally at the predilection sites of fatty streaks and spots an increase in permeability of the endothelium.
      Together with the increased permeability a significant extrusion of acid mucopolysaccharides was observed. These results suggest that mucopolysaccharides could play a passage-restricting role in the aortic endothelium.


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