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Regression of atherosclerosis in rabbits

Part 1. treatment with low-fat diet, hyperoxia and hypolipidemic agents
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      Abstract

      The regression of rabbit atherosclerosis by means of a low-fat diet and hyperoxia either alone or in combination with cholestyramine or estrogen was investigated. During the induction period of 14 weeks, moderate to severe atherosclerosis was produced in male New Zealand rabbits by feeding them a high-cholesterol diet. The rabbits were then divided into various treatment groups. During an additional 10 week regression phase, all animals except those in one group were fed a low-fat diet. Serum lipids, which increased considerably during the induction period, were reduced by all treatments but most effectively by a low-fat diet combined with cholestyramine or with hyperoxia plus cholestyramine. There was little evidence for regression of lesions resulting from a low-fat diet alone. Evidence for regression of lesions was most apparent in rabbits treated with a combination of a low-fat diet and hyperoxia with either cholestyramine and/or estrogen. These results suggest a substantial additive beneficial effect of the combined therapy.

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