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Abstract
The effect of essential oil of garlic on serum fibrinolytic activity has been studied
in 10 healthy individuals (group I); 10 patients with old myocardial infarction (group
II) and in 20 patients with acute myocardial infarction (group III). Garlic was administered
at the dosage equivalent to the essential oil extracted from 1 g of raw garlic per
kg body weight.
Groups I and II were administered garlic for a period of three months. Blood samples
were collected initially, then monthly for the next 5 months. Group III was followed
for 40 days and were allocated to two sub-groups, one receiving garlic and the other
a placebo during the first 20 days only.
Garlic increased fibrinolytic activity by 130% in group I and by 83% in group II at
the end of 3 months. In group III the increase was by 63 and 95.5% above the post-infarction
value after 10 and 20 days respectively. In the placebo-treated acute myocardial infarction
subgroup the increase was only 24% at the end of 20 days. Thus, garlic is of value
in effectively increasing fibrinolytic activity, both during long term use in chronic
infarction cases as well as during the critical acute post-infarction period. The
possible therapeutic role of essential oil of garlic in coronary artery disease has
been discussed.
Keywords
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References
- Fibrinolytic activity and CAD.Lancet. 1968; 1: 987
- Fibrinolysis in patients with ischemic heart disease.Jap. Circulat. J. 1975; 39: 525
- Effect of the essential oils of garlic and onion on alimentary hyperlipemia.Atherosclerosis. 1975; 21: 15
- The protective action of essential oils of onion and garlic in cholesterol-fed rabbits.Atherosclerosis. 1975; 22: 103
- Technical methods.in: Human Blood Coagulation and its Disorders. Blackwell, Oxford1962: 395 (Appendix 3)
- Fibrinolytic activity in acute myocardial infarction.Am. J. Clin. Pathol. 1972; 57: 359
- Fibrinolytic effects of Diguanide plus ethyloestrenol in occlusive vascular disease.Lancet. 1967; 2: 1008
- Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits.Atherosclerosis. 1977; 26: 379
Article Info
Publication History
Accepted:
June 29,
1977
Received in revised form:
June 27,
1977
Received:
April 5,
1977
Footnotes
☆This study was supported by grants from Bombay Hospital Research Centre and the Council of Scientific and Industrial Research.
Identification
Copyright
© 1977 Published by Elsevier Inc.
