Advertisement

Artefacts of localization of atherosclerosis in pinned aortas

  • Margot R. Roach
    Correspondence
    Address for correspondence: Margot R. Roach, M.D., Ph.D., Depts. of Biophysics and Medicine, University of Western Ontario, London, Ont. N6A 5C1, Canada.
    Affiliations
    Departments of Biophysics and Medicine, University of Western Ontario, University Hospital, London, Ont., Canada

    Department of Medicine, University Hospital, London, Ont., Canada
    Search for articles by this author
  • Patricia Hinton
    Affiliations
    Departments of Biophysics and Medicine, University of Western Ontario, University Hospital, London, Ont., Canada

    Department of Medicine, University Hospital, London, Ont., Canada
    Search for articles by this author
  • Joan Fletcher
    Affiliations
    Departments of Biophysics and Medicine, University of Western Ontario, University Hospital, London, Ont., Canada

    Department of Medicine, University Hospital, London, Ont., Canada
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Detailed studies of aortas from 8 rabbits showed that serious artefacts occur if the aortas are pinned at their in vivo dimensions, rather than fixed at physiological pressure. In the pinned aortas, the proximal parts of the branches were pulled up onto the aortic wall. This was more pronounced for the large branches of the abdominal aorta than for the smaller intercostal branches. This artefact caused atherosclerotic lesions, which had developed at the origin of the branch, to appear as if they were entirely on the aortic wall. We found that a marked change in the elastin pattern was present at the origin of the branch; this can be used to mark the true origin of the branch.
      With the pressure technique we found that lesions had different shapes and locations at different branch points.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Roach M.R.
        The effects of bifurcations and stenoses on arterial disease.
        in: Hwang N.H.C. Normann N.A. Cardiovascular Flow Dynamics and Measurements. University Park Press, Baltimore, MD1977: 489-539
        • Corhhill J.F.
        • Roach M.R.
        Quantitative method for evaluation of atherosclerotic lesions.
        Atherosclerosis. 1974; 20: 131-136
        • Wolinsky H.
        • Glagov S.
        Structural basis for the static mechanical properties of the aortic media.
        Circ. Res. 1964; 14: 400-413
        • Burton A.C.
        The stretching of pores in a membrane.
        in: Bolis L. Katchalsky A. Keynes R.D. Loewenstein W.R. Pethica B.A. Permeability and Function of Biological Membranes. North-Holland Publishing Co, Amsterdam1970: 1-19
        • Fry D.L.
        Certain histological and chemical responses of the vascular interface to acutely induced mechanical stress in the aorta of the dog.
        Circ. Res. 1969; 24: 93-108
        • Caro C.G.
        • Fitz-Gerald J.M.
        • Schroter R.C.
        Atheroma and arterial wall shear - Observation, correlation and proposal of a shear-dependent mass transfer mechanism for atherogenesis.
        in: Proc. Roy. Soc. (Biol.). 177. 1971: 109-159