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Research paper| Volume 31, ISSUE 1, P11-20, September 1978

Significance of luminal plasma layer resistance in arterial wall oxygen supply

DOI:https://doi.org/10.1016/0021-9150(78)90032-1
Significance of luminal plasma layer resistance in arterial wall oxygen supply
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      Abstract

      Previous analyses of the arterial wall oxygen supply system have assumed that a cell-free layer of plasma next to the endothelium is the major transport barrier in the lumen. Using a computer simulation, we have quantitatively tested this assumption. Our results show that oxygen diffusion gradients extend significantly into the flowing blood well beyond any plasma layer and that the major luminal transport resistance lies in the flowing blood and not in the plasma layer. The simulation was also employed to compute the effect of a reported 50% drop in plasma oxygen diffusivity. This rather large reduction did significantly lower oxygen levels within the arterial wall tissue. Whether such large reductions in diffusivity ever actually occur in human plasma is a subject of current controversy.

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      Article info

      Publication history

      Accepted: June 6, 1978
      Received in revised form: June 1, 1978
      Received: October 11, 1977

      Footnotes

      ☆This study was supported by National Institutes of Health, USPHS, grants GM-00874, HL-01979, and HL-17517, by Grants-in-Aid from the Chicago and American Heart Associations, and by Evanston Hospital.

      ☆☆Part of the work reported here is from the Ph.D. thesis of Gary Schneiderman. This part was presented in Paper 13d at the 67th Annual Meeting of the American Institute of Chemical Engineers, December 2, 1974, Washington, DC.

      Identification

      DOI: https://doi.org/10.1016/0021-9150(78)90032-1

      Copyright

      © 1978 Published by Elsevier Inc.

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