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Abstract
An intravenous fat tolerance test (IVFTT) was performed and fasting plasma lipid values
determined in 12 healthy normal weight, 18 obese non-diabetic, 9 obese chemical diabetic
and 10 obese symptomatic diabetic African subjects. Their insulin responses to an
oral glucose load were also determined. Mean plasma triglyceride levels were similar
in the normal weight and obese non-diabetic groups but were significantly raised in
the two diabetic groups, being highest in the symptomatic diabetics. The fractional
removal-rate of an intravenous injection of the fat emulsion Intralipid® was significantly less in each of the obese diabetic groups compared with the normal
weight or obese non-diabetic group. There was a significant negative correlation in
all but the symptomatic diabetic group between the fasting triglyceride level and
the rate constants for the IVFTT. These results suggest that the rate of triglyceride
clearance is an important determinant of the basal plasma triglyceride concentration
in urban African subjects.
Keywords
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Article info
Publication history
Accepted:
May 26,
1978
Received in revised form:
May 22,
1978
Received:
March 20,
1978
Footnotes
☆This study was supported by grants from the South African Medical Research Council and Atomic Energy Boards.
Identification
Copyright
© 1978 Published by Elsevier Inc.
