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Cholesterol vehicle in experimental atherosclerosis

Part 16. Effect of peanut oil on pre-established lesions
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      Abstract

      Rabbits were fed an atherogenic diet (2% cholesterol and 6% corn oil) for 8 weeks and then divided into groups of equal average serum cholesterol levels. One group was autopsied, and the others were returned to cholesterol-free diets consisting of commercial laboratory ration or ration augmented with 6% corn oil, peanut oil or PGF, a fat designed to resemble peanut oil minus arachidic and behenic acids. The animals were maintained on the diets for 8 more weeks. On all regimens, severity of atherosclerosis was exacerbated. The extent of exacerbation was significantly less in rabbits fed corn oil than in the others. The extent of exacerbation of lesions appears to be a function of the level of unsaturation of the dietary fats.

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      References

        • Kritchevsky D.
        • Tepper S.A.
        Cholesterol vehicle in experimental atherosclerosis, Part 5 (Influence of fats ana fatty acids on pre-established atheroma).
        J. Atheroscler. Res. 1962; 2: 471-477
        • Kritchevsky D.
        • Tepper S.A.
        Influence of D- and L-thyroxine on pre-established atheromata in rabbits- Effect on mode of administration.
        J. Atheroscler. Res. 1967; 7: 103-110
        • Kritchevsky D.
        • Sallata P.
        • Tepper S.A.
        Influence of ethyl p-chlorophenoxyisobutyrate (CPIB) upon establishment and progression of experimental atherosclerosis in rabbits.
        J. Atheroscler. Res. 1968; 8: 755-761
        • Kritchevsky D.
        • Kim H.K.
        • Tepper S.A.
        Effect of colestipol (U-26597A) on experimental atherosclerosis in rabbits.
        in: Proc. Soc. Exp. Biol. Med.142. 1973: 185-188
        • Vles R.D.
        • Buller J.
        • Gottenbos J.J.
        • Thomasson H.J.
        Influence of type of dietary fat on cholesterol-reduced atherosclerosis in the rabbit.
        J. Atheroscler. Res. 1964; 4: 170-183
        • Gresham G.A.
        • Howard A.N.
        The independent production of atherosclerosis and thrombosis in the rat.
        Brit. J. Exp. Path. 1960; 41: 395-402
        • Vesselinovitch D.
        • Getz G.S.
        • Hughes R.H.
        • Wissler R.W.
        Atherosclerosis in the rhesus monkey fed three food fats.
        Atherosclerosis. 1974; 20: 303-321
        • Kritchevsky D.
        • Tepper S.A.
        • Vesselinovitch D.
        • Wissler R.W.
        Cholesterol vehicle in experimental atherosclerosis, Part II (Peanut oil).
        Atherosclerosis. 1971; 14: 53-64
        • Kritchevsky D.
        • Tepper S.A.
        • Vesselinovitch D.
        • Wissler R.W.
        Cholesterol vehicle in experimental atherosclerosis, Part 13 (Randomized peanut oil).
        Atherosclerosis. 1973; 17: 225-243
        • Mann G.V.
        A method for measurement of cholesterol in blood serum.
        Clin. Chem. 1961; 2: 275-284
        • Duff G.L.
        • McMillan G.C.
        The effect of alloxan diabetes on experimental atherosclerosis in the rabbit.
        J. Exp. Med. 1949; 89: 611-630
        • Kritchevsky D.
        • Moyer A.W.
        • Tesar W.C.
        • Logan J.B.
        • Brown R.A.
        • Davies M.C.
        • Cox H.R.
        Effect of cholesterol vehicle in experimental atherosclerosis.
        Amer. J. Physiol. 1954; 178: 30-32
        • Kritchevsky D.
        • Moyer A.W.
        • Tesar W.C.
        • McCandless R.F.J.
        • Logan J.B.
        • Brown R.A.
        • Englert M.E.
        Cholesterol vehicle in experimental atherosclerosis, Part 2 (Influence of unsaturation).
        Amer. J. Physiol. 1956; 185: 279-280
        • Kritchevsky D.
        • Tepper S.A.
        Effect of coconut oil on pre-established atheromata in rabbits.
        Naturwiss. 1964; 51: 314-315