Aortic cholesteryl esterase

Influence of bile salts
      This paper is only available as a PDF. To read, Please Download here.


      The in vitro activity of cholesteryl ester hydrolase preparations of rat and rabbit aortas was assayed in the presence of the taurine and glycine conjugates of cholic, chenodeoxycholic, deoxycholic and lithocholic acids or in the presence of Triton X-100 and Tween-20. Maximum activity was obtained with tauro- or glycocholic acids. As in the case of pancreatic cholesteryl esterase, trihydroxycholanoic acid derivatives may serve an obligatory function.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Desnuelle P.
        • Savary P.
        Specificities of lipases.
        J. Lipid Res. 1963; 4: 369-384
        • Mahadevan S.
        • Ayyoub N.I.
        • Roels O.A.
        Hydrolysis of retinol palmitate by rat liver.
        J. Biol. Chem. 1966; 241: 57-64
        • Mahadevan S.
        • Tappel A.
        Lysomal lipases of rat liver.
        J. Biol. Chem. 19682; 243: 2849-2854
        • Hyun J.
        • Kothari H.
        • Herm E.
        • Mortensen J.
        • Treadwell C.R.
        • Vahouny G.V.
        Purification and properties of pancreatic juice cholesterol esterase.
        J. Biol. Chem. 19691; 244: 1937-1945
        • Kothari H.V.
        • Miller B.F.
        • Kritchevsky D.
        Aortic cholesterol esterase - Characteristics of normal rat and rabbit enzyme.
        Biochim. Biophys. Acta. 1973; 29: 446-454
        • Kothari H.V.
        • Kritchevsky D.
        Purification and properties of aortic cholesteryl ester hydrolase.
        Lipids. 1975; 10: 322-330
        • Lowry O.H.
        • Rosebrough N.J.
        • Farr A.L.
        • Randall R.J.
        Determination of protein by the Folin phenol reagent.
        J. Biol. Chem. 1951; 193: 265-275
        • Kritchevsky D.
        • Tepper S.A.
        • Rothblat G.H.
        Effect of bile salts on hydrolysis of cholesteryl oleate by rabbit aorta.
        Lipids. 1968; 3: 454-455
        • Goodman D.S.
        • Deykin D.
        • Shiratori T.
        The formation of cholesterol esters in the rat liver enzymes.
        J. Biol. Chem. 1964; 239: 1335-1345
        • Takeuchi T.
        • Yamamura Y.
        Cholesterol esterification and cholesterol ester hydrolysis by liver homogenates in rats with accelerated cholesterol metabolism.
        Atherosclerosis. 1973; 17: 211-224
        • Neelon V.J.
        • Lack L.
        The effect of bile salts on the formation and hydrolysis of cholesterol esters by rat liver enzymes.
        Biochim. Biophys. Acta. 1977; 487: 137-144
        • Stokke K.T.
        The existence of an acid cholesterol esterase in human liver.
        Biochim. Biophys. Acta. 1972; 270: 156-166