Immune mechanisms in patients with proven vascular disease

      This paper is only available as a PDF. To read, Please Download here.


      Lymphocyte transformation and serum levels of immunoglobulins and complement were measured in groups of patients with old myocardial infarction, with peripheral vascular disease and in age- and sex-matched controls. There were no significant differences between the groups in phytohaemagglutinin (PHA) induced lymphocyte transformation, in IgA or in serum complement levels. The levels of IgG and IgM were significantly raised in patients with old proven infarcts while the level of IgM was raised in patients with peripheral vascular disease.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Schwartz C.J.
        • Mitchell J.R.A.
        Cellular infiltration of the human arterial adventitia associated with atheromatous plaques.
        Circulation. 1962; 26: 73
        • Davies D.F.
        • Clark A.J.
        Increase in gamma globulin in coronary heart disease.
        J. Atheroscler. Res. 1968; 8: 724
        • Davies D.F.
        • Johnson A.P.
        • Rees B.W.G.
        • Elwood P.C.
        • Abernethy M.
        Food antibodies and myocardial infarction.
        Lancet. 1974; 1: 1012
        • Poston R.N.
        • Davies D.F.
        Immunity and inflammation in the pathogenesis of atherosclerosis.
        Atherosclerosis. 1974; 19: 353
        • Perper R.J.
        • Zee T.W.
        • Mickelson M.M.
        Purification of lymphocytes and platelets by gradient centrifugation.
        J. Lab. Clin. Med. 1968; 72: 842
        • Penhale W.J.
        • Farmer A.
        • MacCuish A.C.
        • Irvine W.J.
        A rapid micro-method for the phytohaemagglutinin-induced human lymphocyte transformation test.
        Clin. Exp. Immunol. 1974; 18: 155
        • Ebringer A.
        • Rosenbaum M.
        • Pincus N.
        • Doyle A.E.
        Changes in serum immunoglobulins after myocardial infarction.
        Amer. J. Med. 1971; 50: 297
        • Hannut R.
        • Lambert A.
        Immunoglobulin sériques en pathologie cardiovasculaire.
        PathologieBiologie. 1975; 23: 265
        • Fiorentini P.
        • Evangelisti G.B.
        • Marabini G.F.
        Gli aspetti autoimmuni del quadre umorale nella malattia arteriosclerotica.
        G. Clin. Med. 1971; 52: 666