Efficacy of hypolipidemic treatment in inhibition of experimental atherosclerosis

The effect of nicotinic acid and related compounds
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      The hypolipidemic and antiatherogenic effects of different nicotinic acid derivatives were studied.
      Five rabbit groups maintained on an atherogenic diet were given simultaneously various nicotinic acid derivatives (50 mg/kg body weight/day): nicotinic acid, Xantinol-nicotinate, β-pyridylcarbinol or Pirozadil (bis-3,4,5-trimethoxybenzoate, 2,6-pyridindiyldimethylene).
      All 4 compounds showed a clear hypocholesterolemic and antiatherogenic effect, as measured by serum cholesterol, and by planimetric evaluation of the aortic lesions in terms of percent surface area affected in the aortas and coronary lumen. The simultaneously observed elevation of the HDL/LDL cholesterol ratio of the aortic tissue possibly indicates an antiatherogenic effect of these changes.


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        • Constantinides P.
        • Booth J.
        • Carlson G.
        Production of advanced cholesterol atherosclerosis in the rabbits.
        Arch. Path. 1960; 70: 712
        • Duff G.L.
        • McMillan G.C.
        The effect of alloxan diabetes on experimental cholesterol atherosclerosis in the rabbit.
        J. Exp. Med. 1949; 89: 611
        • Kritchevsky D.
        • Moynihan J.L.
        • Langan J.
        • Tepper S.A.
        • Sachs M.L.
        Effects of D- and L-thyroxine and of D- and L-3,5,5'-triiodothyronine on development and regression of experimental atherosclerosis in rabbits.
        J. Atheroscler. Res. 1961; 1: 211
        • Parwaresch M.R.
        • Mäder Ch.
        • Hill W.
        • Wiswedel K.
        Ein kombiniertes Verfahren zur Erzeugung von Arteriosklerose bei Kaninchen in Kurzzeitversuchen.
        Res. Exp. Med. 1973; 160: 269
        • Mettler L.
        • Parwaresch M.R.
        Morphologische and biochemische Untersuchungen über die präventive Wirkung von Östorgen (Östradiol) auf eine lipidinduzierte Arteriosklerose.
        Geburtsh. Frauenheilk. 1972; 32: 426
        • Altschul R.
        Die Beeinflussung des Blut-Cholesterinspiegels and der experimentellen Atherosklerose durch Nikotinsäure.
        Z. Kreislaufforsch. 1956; 45: 573
        • Cava E.E.
        • Achor R.W.P.
        • Berge K.G.
        • Wakim K.G.
        • Edwards J.E.
        • McKenzie B.F.
        • Barker N.W.
        Effect of nicotinic acid on experimental atheromatosis of rabbits.
        in: 2nd edition. Proc. Mayo Clin.34. 1959: 502
        • Merrill J.M.
        • Lemley-Stone J.
        Effects of nicotinic acid on serum and tissue cholesterol in rabbits.
        Circ. Res. 1957; 5: 617
        • Folch J.
        • Lees M.
        • Stanley G.H.
        A simple method for the isolation and purification of total lipids from animal tissues.
        J. Biol. Chem. 1957; 226: 497
        • Röschlau P.
        • Bernt E.
        • Gruber W.
        Enzymatische Bestimmung des Gesamt-Cholesterins im Serum.
        Z. Klin. Chem. Klin. Biochem. 1974; 12: 403
        • Hasch F.T.
        • Lees R.S.
        Practical methods for plasma lipoprotein analysis.
        Adv. Lipid Res. 1968; 6: 1
        • Parwaresch M.R.
        • Radzun H.J.
        • Mäder Ch.
        Diagnose primärer Hyperlipoproteinamien im Nabelschnurblut.
        Mschr. Kinderheilk. 1977; 125: 865
        • Kritchevsky D.
        • Tepper S.A.
        Cholesterol vehicle in experimental atherosclerosis, Part 8 (Effect of medium chain triglyceride (MCT)).
        Exp. Mol. Path. 1965; 4: 489
        • Kritchevsky D.
        • Tepper S.A.
        • Kim H.K.
        • Moses D.E.
        • Story J.A.
        Experimental atherosclerosis in rabbits fed cholesterol-free diets.
        Exp. Mol. Path. 1975; 22: 11