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Abstract
The effect of bezafibrate in the dosages 450, 900 and 1350 mg daily on serum lipoprotein
concentrations were studied in 20 subjects with primary hyperlipoproteinaemia (16
of type IV, 2 of type II B, 1 of type III). Except for LDL cholesterol maximum effects
were obtained with 450 mg daily. Total serum cholesterol and triglycerides (TG) fell
significantly. Mean very low density lipoprotein (VLDL) TG fell by 54%. The maximum
effect on low density lipoprotein was obtained with 900 mg daily. The effect was highly
dependent on initial concentrations, decreases being observed above 4 mmoles/1 and
increases below that concentration. High density lipoprotein cholesterol increased
by 31% (P < 0.01) independently of the VLDL decrease. Three subjects suffered gastrointestinal
side-effects on 1350 mg daily. Only benign reversible changes were noted on non-lipid
measurements. Bezafibrate is a well-tolerated drug with a good VLDL TG lowering effect.
It is particularly effective in increasing HDL cholesterol concentrations.
Keywords
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Adam, O., Wolfram, G., Lang, P.D. and Zöllner, N., Dosiswirkungsuntersuchung mit Bezafibrat an Patienten mit Hypercholesterinämie and Hypertriglyceridimie, Münch. Med. Wschr., In press.
Article info
Publication history
Accepted:
August 4,
1978
Received in revised form:
August 2,
1978
Received:
June 7,
1978
Identification
Copyright
© 1978 Published by Elsevier Inc.
