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Abstract
The effect of bezafibrate (2-{4-[2-(4-chlorobenzamido)-ethyl]-phenoxy}-2-methylpropionic
acid) (450 mg daily) on serum lipoprotein concentrations was studied for 1 year in
14 subjects with hyperlipoproteinaemia (3 of type II A, 2 of type II B, 2 of type
III and 7 of type IV). After 2 months serum cholesterol decreased from 7.12−6.08 mmoles/l
(15%, P < 0.01), triglycerides from 2.52−1.96 mmoles/1 (22%, P < 0.01), very low density lipoprotein triglycerides from 1.48−0.86 mmoles/1 (42%,
P < 0.01) and low density lipoprotein cholesterol from 5.00−3.81 mmoles/1 (24%, P < 0.01). While triglyceride concentrations of serum and lipoproteins remained constant
for 1 year, serum and LDL cholesterol concentrations increased slightly after 6 and
12 months. The former rise was partly due also to a rise of the possibly beneficial
high density lipoprotein cholesterol from 1.27−1.68 mmoles/1 (32%, P < 0.01) after 6 months, making the effect on total cholesterol less pronounced.
Subjective side-effects were nausea in one patient. No severe biochemical side-effects
were noted.
Keywords
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References
- Effect of BM 15.075 on lipoprotein concentrations in different types of hyperlipoproteinaemia.Atherosclerosis. 1977; 27: 279-287
- Dose-response study of bezafibrate on serum lipoprotein concentrations in hyperlipoproteinaemia.Atherosclerosis. 1978; 31: 421
Wallmüller, A., Adam, O., Wolfram, C. and Zöllner, N., Dosiswirkungsbeziehung von Bezafibrat bei Patienten mit Hypercholesterinämie and Hypertriglyceridämie, In preparation.
- Long-term results with bezafibrate, a new derivate of clofibrate.in: Carlson L.A. Paoletti R. Weber G. International Conference on Atherosclerosis, Milan, November 1977 Raven Press, New York, NY1978: 129
- Use of a single color reagent to improve the automated determination of serum total cholesterol.in: 3rd edition. Automation in Analytical Chemistry. Vol. 1. Mediad Inc, New York, NY1965: 345
- Fluorimetric measurements of triglycerides.in: 3rd edition. Automation in Analytical Chemistry. Vol. 1. Mediad Inc, New York, NY1965: 341
- Lipoprotein fractionation.J. Clin. Path. 1973; 26 (Suppl. (Ass. Clin, Path.)): 32-37
- Classification of hyperlipidaemias and hyperlipoproteinaemias.Bull. Wld Hlth Org. 1970; 43: 891
- High density lipoprotein and atherosclerosis.Lancet. 1975; 1: 1033
Article info
Publication history
Accepted:
August 4,
1978
Received in revised form:
August 2,
1978
Received:
June 7,
1978
Identification
Copyright
© 1978 Published by Elsevier Inc.
