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One-year study of the effect of bezafibrate on serum lipoprotein concentrations in hyperlipoproteinaemia

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      Abstract

      The effect of bezafibrate (2-{4-[2-(4-chlorobenzamido)-ethyl]-phenoxy}-2-methylpropionic acid) (450 mg daily) on serum lipoprotein concentrations was studied for 1 year in 14 subjects with hyperlipoproteinaemia (3 of type II A, 2 of type II B, 2 of type III and 7 of type IV). After 2 months serum cholesterol decreased from 7.12−6.08 mmoles/l (15%, P < 0.01), triglycerides from 2.52−1.96 mmoles/1 (22%, P < 0.01), very low density lipoprotein triglycerides from 1.48−0.86 mmoles/1 (42%, P < 0.01) and low density lipoprotein cholesterol from 5.00−3.81 mmoles/1 (24%, P < 0.01). While triglyceride concentrations of serum and lipoproteins remained constant for 1 year, serum and LDL cholesterol concentrations increased slightly after 6 and 12 months. The former rise was partly due also to a rise of the possibly beneficial high density lipoprotein cholesterol from 1.27−1.68 mmoles/1 (32%, P < 0.01) after 6 months, making the effect on total cholesterol less pronounced.
      Subjective side-effects were nausea in one patient. No severe biochemical side-effects were noted.

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