The relation of hypercholesterolemic fatty streaks to intimal permeability changes shown by Evans blue

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      The aortic localization of diet-induced fatty streaks in relation to focal increases in intimal permeability was evaluated in cynomolgus monkeys. Animals fed a hypercholesterolemic diet and studied at 10, 15, and 100 days had increasing intensity of Evans blue dye uptake. The overlap of fatty streaks with areas of dye intake increased as the areas of dye uptake enlarged, but all hypercholesterolemic groups showed some fatty streaks not topographically related to areas of dye uptake or of flow instability. Because the upper thoracic aorta tended to show more advanced fatty streak formation dissociated from evident permeability change or hydraulic instability, it is suggested that mechanical factors associated with the geometric configuration of the descending thoracic aorta may have a significant role in the localization of some hypercholesterolemic fatty streaks.


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        • Stefanovitch V.
        • Gore I.
        Cholesterol diet and permeability of rabbit aorta.
        Exp. Mol. Path. 1971; 14: 20
        • Weber G.
        • Fabbrini P.
        • Resi L.
        Scanning and transmission electron microscopy observations on the surface lining of aortic intimal plagues in rabbits on a hypercholesterolic diet.
        Virchows Arch. Path. Anat. A. 1974; 364: 325
        • Ross R.
        • Harker L.
        Hyperlipidemia and atherosclerosis.
        Science. 1976; 193: 1094
        • Armstrong M.L.
        • Connor W.E.
        • Warner E.D.
        Xanthomatosis in rhesus monkeys fed a hypercholesterolemic diet.
        Arch. Path. 1967; 84: 227
        • Abell L.L.
        • Levy E.B.
        • Brodie B.B.
        • Kendall F.E.
        Simplified method for the estimation of total cholesterol and demonstration of its specificity.
        J. Biol. Chem. 1952; 195: 357
      1. 3rd edition. Manual of Laboratory Operations, Lipid Research Clinics Program, Vol. 1 (Lipid and Lipoprotein Analysis), DHEW Publication No. (NIH) 75–628. May 1974: 9
        • Kent T.H.
        • Reynolds J.M.
        Gross specimen photography.
        Pathology Education Bulletin of the Group for Research in Pathology Education. 1977; 3: 11
        • Wissler R.W.
        Workshop on the arterial wall and the pathogenesis of atherosclerosis, discussion.
        in: Schettler G. Weizel A. Atherosclerosis III. Springer-Verlag, New York, NY1974: 25
        • Bondjers G.
        • Hansson G.
        • Brattsand R.
        • Björkerud S.
        The effect of moderate increases in serum cholesterol on the blood-artery cholesterol transfer barrier.
        in: 3rd edition. Advances in Experimental Medicine and Biology. Vol. 82. Plenum Press, New York, NY1977: 237-239
        • Friedman M.
        • Byers S.O.
        Endothelial permeability in atherosclerosis.
        Arch. Path. 1963; 76: 99
        • Minick C.R.
        • Stemerman M.G.
        • Insull Jr., W.
        Effect of regenerated endothelium on lipid accumulation in the arterial wall.
        in: 3rd edition. Proc. Nat. Acad. Sci. (U.S.A.). 74. 1977: 1724
        • Gerrity R.G.
        • Schwartz C.J.
        Endothelial cell injury in early hypercholesterolemia.
        Circulation. 1977; 56: 92
        • Bierring F.
        • Kobayasi T.
        Electron microscopy of the normal rabbit aorta.
        Acta Path. Microbiol. Scand. 1963; 57: 154
        • Adams C.W.M.
        Vascular Histochemistry.
        in: Year Book Medical Publishers, Chicago, IL1967: 35
        • Bredt H.
        in: Schettler F.G. Boyd G.S. Atherosclerosis. Elsevier, Amsterdam1969: 31-32
        • Kramsch D.M.
        • Hollander W.
        Occlusive atherosclerotic disease of the coronary arteries in monkey (Macaca irus) induced by diet.
        Exp. Mol. Path. 1968; 9: 1
        • Armstrong M.L.
        Atherosclerosis in rhesus and cynomolgus monkeys.
        in: 3rd edition. Primates in Medicine. Vol. 9. S. Karger, Basle1976: 16-40
        • Newman D.L.
        • Batten J.R.
        • Bowen N.L.R.
        Influence of experimental stenosis on uptake of albumin by the abdominal aorta.
        Atherosclerosis. 1977; 26: 195
        • Weinbaum S.
        • Lewis C.T.
        • Caro C.J.
        Theoretical models and electronmicroscopic studies on the transport of macromolecules across arterial endothelium and their uptake by the arterial wall.
        in: Proceedings from a Specialists Meeting on Fluid Dynamic Aspects of Arterial Disease. Ohio State University, Columbus, OH1974
        • Bell F.P.
        • Adamson I.L.
        • Schwartz C.J.
        Aortic endothelial permeability to albumin — Focal and regional patterns of uptake and transmural distribution of 131I-albumin in the young pig.
        Exp. Mol. Path. 1974; 20: 57
        • Bell F.P.
        • Gallus A.S.
        • Schwartz C.J.
        Focal and regional patterns of uptake and the transmural distribution of 131I-fibrinogen in the pig aorta in vivo.
        Exp. Mol. Path. 1974; 20: 281
        • Gerrity R.C.
        • Richardson Mary
        • Somer J.B.
        • Bell F.P.
        • Schwartz C.J.
        Endothelial cell morphology in areas of in vivo Evans' blue uptake in the aorta of young pigs, Part 2 (Ultrastructure of the intima in areas of differing permeability to protein).
        Amer. J. Path. 1977; 89: 313
        • Day A.J.
        • Bell F.P.
        • Schwartz C.J.
        Lipid metabolism in focal areas of normal-fed and cholesterol-fed pig aorta.
        Exp. Mol. Path. 1974; 21: 179
        • Bell F.P.
        • Day A.J.
        • Gent M.
        • Schwartz C.J.
        Differing patterns of cholesterol accumulation and 3H-cholesterol influx in areas of the cholesterol-fed pig aorta identified by Evans' blue dye.
        Exp. Mol, Path. 1975; 22: 366