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Abstract
Early changes in cholesteryl ester metabolism of the aorta during the regression of
naturally occurring atherosclerotic lesions in pigeon aorta by ileal bypass surgery
were examined. Three months after surgery, there was a decrease (50%) in the content
of cholesteryl esters in the aorta. Increases in the activity of cholesteryl ester
hydrolase in the lysosomal (P < 0.05) and the supernatant (P < 0.01) fractions of the aorta also occurred at this time. There were no differences
in the activity of cholesteryl ester synthetase and in the plasma levels of cholesterol
and triglycerides between the ileal bypass group and the controls. These results suggest
that ileal bypass surgery decreases the level of cholesteryl esters in the aorta,
probably because of enhanced cholesteryl ester hydrolysis.
Keywords
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Article info
Publication history
Accepted:
June 21,
1978
Received in revised form:
June 15,
1978
Received:
September 20,
1977
Footnotes
☆This investigation was supported in part by Research Grant HL-14196 from the National Institutes of Health, Public Health Service.
Identification
Copyright
© 1978 Published by Elsevier Inc.
