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Platelet aggregation studies in coronary artery disease

Past 4. Effect of aspirin
  • J. Mehta
    Correspondence
    Address for correspondence: J. Mehta, M.D., Division of Cardiology, Department of Medicine, Box J-277, JHM Health Center, Gainesville, FL 32610, U.S.A.
    Affiliations
    Cardiovascular and Hematology Divisions, Departments of Medicine and Pediatrics, University of Florida and Veterans Administration Hospital, Gainesville, FL 32610 U.S.A.
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  • P. Mehta
    Affiliations
    Cardiovascular and Hematology Divisions, Departments of Medicine and Pediatrics, University of Florida and Veterans Administration Hospital, Gainesville, FL 32610 U.S.A.
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  • C. Burger
    Affiliations
    Cardiovascular and Hematology Divisions, Departments of Medicine and Pediatrics, University of Florida and Veterans Administration Hospital, Gainesville, FL 32610 U.S.A.
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  • C.J. Pepine
    Affiliations
    Cardiovascular and Hematology Divisions, Departments of Medicine and Pediatrics, University of Florida and Veterans Administration Hospital, Gainesville, FL 32610 U.S.A.
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      Abstract

      We evaluated platelet aggregation in vitro in blood samples drawn simultaneously from aorta and coronary sinus. Platelet aggregation was significantly lower in the coronary venous blood than in the aortic blood in patients with coronary artery disease. Lower platelet counts were also observed in coronary venous blood. No such differences were seen in subjects with normal coronary arteries. Oral administration of aspirin eliminated the differences in platelet aggregation and counts across the myocardial vascular bed. These observations suggest that platelet sequestration in the myocardial vasculature may be related to the presence of disease in the coronary arteries.

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