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Research paper| Volume 41, ISSUE 1, P53-60, January 1982

Metformin reduces platelet hypersensitivity in hypercholesterolemic rabbits

DOI:https://doi.org/10.1016/0021-9150(82)90069-7
Metformin reduces platelet hypersensitivity in hypercholesterolemic rabbits
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      Abstract

      The effects of Metformin treatment on platelet responsiveness to aggregating agents was studied in cholesterol-fed rabbits. Three groups of animals were fed, for one month, either a normal (N), or a hypercholesterolemic (HC), or a hypercholesterolemic + 0.5% Metformin diet (HC + Met). Platelets from the HC rabbits required significantly lower collagen and arachidonic acid concentrations to aggregate, as compared to platelets from N rabbits. The platelet response from the HC + Met rabbits was not significantly different from that of normals. The cholesterol/phospholipid ratio in platelets was increased in both dietary groups (HC, HC + Met). The serum thromboxane B2 concentrations did not show any significant difference between the groups. Plasma exchange experiments failed to indicate a specific effect of the plasma environment on platelet behaviour. In view of the inactivity of metformin on the platelet cyclooxygenase pathway, the reported results suggest that metformin may act by an as yet unexplored mechanism.

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      Article info

      Publication history

      Accepted: May 4, 1981
      Received in revised form: April 30, 1981
      Received: December 10, 1980

      Footnotes

      ☆Supported in part by Grant RF1-7901086.83 of the Consiglio Nazionale delle Ricerche of Italy.

      ☆☆Presented in part at the 5th International Symposium on Atherosclerosis, Houston, TX, November 1979.

      Identification

      DOI: https://doi.org/10.1016/0021-9150(82)90069-7

      Copyright

      © 1982 Published by Elsevier Inc.

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