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Research paper| Volume 41, ISSUE 1, P61-65, January 1982

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Rapid and substantial lowering of human serum cholesterol by mevinolin (MK-803), an inhibitor of hydroxymethylglutaryl-coenzyme a reductase

DOI:https://doi.org/10.1016/0021-9150(82)90070-3
Rapid and substantial lowering of human serum cholesterol by mevinolin (MK-803), an inhibitor of hydroxymethylglutaryl-coenzyme a reductase
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      Abstract

      Mevinolin (MK-803) is a potent inhibitor of HMG-CoA reductase. After a placebo run-in period, mevinolin 5, 15 or 50 mg, or placebo was given twice daily for 7–11 days under double-blind conditions to 4 groups of 6 normocholesterolemic male volunteers. After 7 days, mean serum cholesterol fell 14%, 25% and 24% on 5, 15 and 50 mg, respectively, which was significantly greater than the fall on placebo (4%) in the case of the two higher doses (P < 0.01). Serum triglycerides did not change significantly. Mevinolin was generally well tolerated and there were no serious adverse effects.

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      Article info

      Publication history

      Accepted: May 4, 1981
      Received in revised form: May 1, 1981
      Received: March 6, 1981

      Identification

      DOI: https://doi.org/10.1016/0021-9150(82)90070-3

      Copyright

      © 1982 Published by Elsevier Inc.

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