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Abstract
Biliary lipid composition and serum VLDL triglyceride (VLDL-TG) level were determined
intermittently over 24 h in 5 previously cholecystectomized hypertriglyceridaemic
patients. The study was repeated when the patients had been treated with clofibrate
for 2 months. Before and during treatment the molar cholesterol concentration in duodenal
bile showed marked diurnal variations. It dropped after the first meal in the morning,
remained depressed until the end of the evening, increased early at night and dropped
back slightly between 2 and 8 a.m. A diurnal variation was also recorded for bile
acid composition, as the contribution of cholic acid (C) increased in 4 of the subjects
at night. During treatment with clofibrate, the molar concentration of cholesterol
remained unchanged during the day but was significantly elevated in samples obtained
at night. The contribution of C increased during both the day and the night. As a
general tendency, changes in the curve representing the molar level of cholesterol
in bile were mirrored by reversed changes in the VLDL level in plasma. The possibility
of a causal relationship between these two parameters is discussed.
Keywords
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Article info
Publication history
Accepted:
May 13,
1981
Received in revised form:
May 13,
1981
Received:
November 17,
1980
Footnotes
☆The study was supported by grants from the Swedish Medical Research Council.
Identification
Copyright
© 1982 Published by Elsevier Inc.
