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Abstract
Changes of plasma levels of apoproteins A-I, A-II and C-III were determined after
oral and intravenous fat administration. The A-I levels increased in three out of
four subjects after fat ingestion but no changes or even a slight decrease in the
levels of A-I were observed after intravenous fat infusion. The A-II levels also increased
after fat ingestion in two subjects but the levels either did not change or decreased
slightly after fat infusion. The levels of C-III increased concomitantly with the
increase of triglyceride levels after fat ingestion as well as fat infusion. After
intravenous fat infusion, part of the C-III in the d > 1.006 fraction shifted to the
lighter fraction (d < 1.006). These observations suggest that the increase in the
levels of A-I and A-II after fat ingestion are a consequence of an increase in apoprotein
synthesis in the intestine during fat absorption. The increase in the levels of C-III
after fat ingestion as well as fat infusion seemed to be related to the capture of
C-III in the triglyceride rich particles, i.e. C-III accumulated in the circulation
with triglyceride-rich particles. However, it appeared also to be possible that the
rate of C-III synthesis increases during hyperlipidemia induced by fat infusion.
Keywords
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Article info
Publication history
Accepted:
May 19,
1981
Received in revised form:
May 18,
1981
Received:
January 5,
1981
Footnotes
☆This work was partly supported by a research grant from the Japan Heart Foundation.
Identification
Copyright
© 1982 Published by Elsevier Inc.
