Influence of native and randomized peanut oil on lipid metabolism and aortic sudanophilia in the vervet monkey

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      Vervet monkeys (Cercopithecus aethiops pygerethrus) were fed cholesterol-free, semipurified diets containing 40% sucrose, 25% casein, 15% cellulose and 14% peanut oil (PNO), randomized peanut oil (RPNO) or corn oil (CO). After 4 months, serum cholesterol and triglyceride levels, serum lecithin-cholesterol acyl transferase (LCAT) activity and plasma lipoprotein lipase (LPL) activity were similar in all groups. Livers of monkeys fed CO converted 156% more acetate and 24% more mevalonate to cholesterol than those of monkeys fed RPNO. Cholesterogenesis in RPNO-fed monkeys was enhanced compared to PNO (68% from acetate; 62% from mevalonate).
      Incidence of atherosclerosis was 33% in monkeys fed RPNO, 80% in those fed CO and 90% in those fed PNO. Extent of sudanophilia was lowest in aortas of monkeys fed RPNO. Incidence of arteriosclerosis was 40% in monkeys fed CO, 56% in those fed RPNO and 70% in those fed PNO. Extent of aortic surface showing arteriosclerosis was highest in monkeys fed RPNO.


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        • Gresham G.A.
        • Howard A.N.
        The independent production of atherosclerosis and thrombosis in the rat.
        Brit. J. Exp. Path. 1960; 41: 395
        • Kritchevsky D.
        • Tepper S.A.
        • Vesselinovitch D.
        • Wissler R.W.
        Cholesterol vehicle in experimental atherosclerosis, Part 11 (Peanut oil).
        Atherosclerosis. 1971; 14: 53
        • Vesselinovitch D.
        • Getz G.S.
        • Hughes R.H.
        • Wissler R.W.
        Atherosclerosis in the Rhesus monkey fed three food fats.
        Atherosclerosis. 1974; 20: 303
        • Kritchevsky D.
        • Tepper S.A.
        • Kim H.K.
        • Story J.A.
        • Vesselinovitch D.
        • Wissler R.W.
        Experimental atherosclerosis in rabbits fed cholesterol-free diets, Part 5 (Comparison of peanut, corn, butter and coconut oils).
        Exp. Mol. Path. 1976; 24: 375
        • Myher J.J.
        • Marai L.
        • Kuksis A.
        • Kritchevsky D.
        Acylglycerol structure of peanut oils of different atherogenic potential.
        Lipids. 1977; 12: 775
        • Kritchevsky D.
        • Tepper S.A.
        • Vesselinovitch D.
        • Wissler R.W.
        Cholesterol vehicle in experimental atherosclerosis, Part 13 (Randomized peanut oil).
        Atherosclerosis. 1973; 17: 225
        • Kritchevsky D.
        • Davidson L.M.
        • Shapiro I.L.
        • Kim H.K.
        • Kitagawa M.
        • Malhotra S.
        • Nair P.P.
        • Clarkson T.B.
        • Bersohn I.
        • Winter P.A.D.
        Lipid metabolism and experimental atherosclerosis in baboons—Influence of cholesterol-free, semi-synthetic diets.
        Amer. J. Clin. Nutr. 1974; 27: 29
        • Kritchevsky D.
        • Davidson L.M.
        • Kim H.K.
        • Krendel D.A.
        • Malhotra S.
        • Vander Watt J.J.
        • Du Plessis J.P.
        • Winter P.A.D.
        • Ipp T.
        • Mendelsohn D.
        • Bersohn L.
        Influence of semi-purified diets on atherosclerosis in African Green monkeys.
        Exp. Mol. Path. 1977; 26: 28
        • Zak B.R.
        • Dickenman R.C.
        • White E.G.
        Rapid estimation of free and total cholesterol.
        Amer. J. Clin. Path. 1954; 24: 1307
        • Van Handel E.
        • Zilversmit D.B.
        Micro-method for the direct determination of serum triglycerides.
        J. Lab. Clin. Med. 1957; 50: 152
        • Lacko A.S.
        • Rutenburg H.L.
        • Soloff L.A.
        Measurement of the initial rate of serum cholesterol esterification.
        Biochem. Med. 1973; 7: 178
        • Krauss R.M.
        • Levy R.I.
        • Fredrickson D.S.
        Selective measurement of two lipase activities in postheparin plasma from normal subjects and patients with hyperlipoproteinemia.
        J. Clin. Invest. 1974; 54: 1107
        • Dempsey M.E.
        Cholesterol biosynthesis in vitro.
        Handbook of Experimental Pharmacology. 1975; (Ch. 41): 1
        • Popjak G.
        Enzymes of sterol biosynthesis in liver and intermediates of sterol biosynthesis.
        Meth. Enzymol. 1969; 15: 393
        • Frantz Jr., I.D.
        • Bucher N.L.R.
        The incorporation of the carboxyl carbon from acetate into cholesterol by rat liver homogenates.
        J. Biol. Chem. 1954; 206: 471
        • Kabara J.J.
        • McLaughlin J.T.
        • Riegel C.A.
        Quantitative microdetermination of cholesterol using tomatine as precipitating agent.
        Anal. Chem. 1961; 33: 305
        • Holman R.L.
        • McGill H.C.
        • Strong J.P.
        • Geer J.C.
        Technics for studying atherosclerosic lesions.
        Lab. Invest. 1958; 7: 42
        • Duff G.L.
        • McMillan G.C.
        The effect of alloxan diabetes on experimental cholesterol atherosclerosis in the rabbit.
        J. Exp. Med. 1949; 89: 611
        • Kritchevsky D.
        • Tepper S.A.
        • Story J.A.
        Cholesterol vehicle in experimental atherosclerosis, Part 16 (Effect of peanut oil on pre-established lesions).
        Atherosclerosis. 1978; 31: 365
        • Mukherjee S.
        • Alfin-Slater R.B.
        The effect of the nature of dietary fat synthesis of cholesterol from acetate-1-C14 in rat liver slices.
        Arch. Biochem. Biophys. 1958; 73: 359
        • Avigan J.
        • Steinberg D.
        Effects of saturated and unsaturated fat on cholesterol metabolism in the rat.
        in: Proc. Soc. Exp. Biol., Med.97. 1958: 814
        • Wilson J.D.
        • Siperstein M.D.
        Effect of saturated and unsaturated fats on hepatic synthesis and biliary excretion of cholesterol by the rat.
        Amer. J. Physiol. 1959; 196: 599
        • Reiser R.
        • Williams M.C.
        • Sorrels M.F.
        • Murty N.L.
        Biosynthesis of fatty acids of cholesterol as related to diet fat.
        Arch. Biochem. Biophys. 1963; 102: 276
        • Kritchevsky D.
        • Tepper S.A.
        Influence of medium chain triglycerides (MCT) on cholesterol metabolism in rats.
        J. Nutr. 1965; 86: 67