Research paper| Volume 42, ISSUE 2-3, P197-203, April 1982

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Discriminative value of lipids and apoproteins in coronary heart disease

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      Serum cholesterol, HDL cholesterol (HDL-C), and apoproteins, A1, A2 and B were determined in 70 male survivors of myocardial infarction and in an equal number of healthy controls, matched for age, sex and body mass index. In univariate analyses, the Apo B/Apo A1 ratio discriminated the best between cases and controls, giving a 72% exact classification. In a multivariate analysis, the Apo B/Apo A1 ratio, HDL-C and the Apo A2/Apo A1 ratio contributed independently to the discrimination of cases from controls while the overall exact classification was 82%. These promising results were comparable in younger and older subgroups.
      Thus, the determination of apoproteins yielded complementary information in this cross-sectional survey and warrants further study in a prospective setting.


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