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Fatty acid oxidation of rat brain microvessels in hypertension, aging and experimental diabetes

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      Abstract

      Microvessels were prepared from rat brain and their fatty acid oxidation was investigated. This activity was much higher in brain microvessels than in other vessels or organs, suggesting that brain microvessels have a high capacity for energy production. The activity was decreased in some pathological conditions, such as hypertension, aging and diabetes mellitus.
      The relationship between changes in fatty acid oxidation activities and injuries of brain microvessels is discussed.

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      References

        • Brendel K.
        • Meezan E.
        • Carlson E.C.
        A purified, metabolically active preparation from bovine cerebral cortex.
        Science. 1974; 185: 953
        • Okamoto K.
        • Aoki K.
        Development of a strain of spontaneously hypertensive rats.
        Jap. Circ. J. 1963; 27: 282
        • Yamori Y.
        Pathogenesis of spontaneously hypertensive rats as a model for essential hypertension.
        Jap. Circ. J. 1977; 41: 259
        • Lowry O.H.
        • Rosenbrough N.J.
        • Farr A.L.
        • Randall R.J.
        Protein measurement with the Folin phenol reagent.
        J. Biol. Chem. 1951; 193: 265
        • Kissane J.M.
        • Robins E.
        The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system.
        J. Biol. Chem. 1958; 233: 184
        • Ooneda G.
        • Yoshida Y.
        • Suzuki K.
        • Sekiguchi T.
        Morphogenesis of plasmatic arterionecrosis as the cause of hypertensive intracerebral hemorrhage.
        Virchows Arch. Abt. A Path. Anat. 1973; 361: 31
        • Yamori Y.
        • Nagaoka A.
        • Okamoto K.
        Importance of genetic factors in stroke — An evidence obtained by selective breeding of stroke-prone and -resistant SHR.
        Jap. Circ. J. 1974; 38: 1095
        • Okamoto K.
        • Yamori Y.
        • Nagaoka A.
        Establishment of the stroke-prone spontaneously hypertensive rat (SHR).
        Circ. Res. 1974; 34: 143