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Abstract
The effect of ciprofibrate, 2[p-(2,2-dichlorocyclopropyl)-phenoxyl]-2-methyl propionic acid, in daily doses of 50,
100 and 200 mg was studied in 50 patients with hyperlipoproteinaemia (21 type IIA,
10 type IIB and 19 type IV). Ciprofibrate was convenient to take and was without subjective
side effects. The greatest hypolipidaemic effects were reached for all lipoproteins
with 200 mg daily. In type IIA and IIB, mean low density lipoprotein (LDL) cholesterol
was normalized on the 200 mg dose. The effect was highly dependent on initial LDL
cholesterol concentrations, decreases being observed above 4 mmol/1 and increases
below that concentration. Mean very low density lipoprotein (VLDL) triglyceride concentrations
decreased on 200 mg per day by 48–59%. HDL cholesterol increased in all types of hyperlipoproteinaemia
by 6–19%, the change being unrelated to changes in VLDL lipids. With a dosage of 200
mg daily the effects were maintained for the following period of 6 months. It is concluded
from this study that it would be appropriate to start patients on 100 mg daily and
then titrate their dose according to response. The optimal dosage for ciprofibrate
seems to be 200 mg daily.
Keywords
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Article info
Publication history
Accepted:
October 13,
1981
Received in revised form:
October 12,
1981
Received:
April 23,
1981
Footnotes
☆Supported by grants from the Swedish Medical Research Council No. 19X-204.
Identification
Copyright
© 1982 Published by Elsevier Inc.
