Rate of LCAT-mediated cholesterol esterification and serum lipids during etiroxate therapy in hyperlipoproteinemia

      This paper is only available as a PDF. To read, Please Download here.


      Changes in the rate of the plasma cholesterol ester production mediated by lecithin: cholesterol acyltransferase (LCAT, E.C. were examined in 15 patients suffering from types II and IV HLP who had been treated for 14 weeks with etiroxate. Whereas the plasma cholesterol concentration decreased significantly only in the initial phase of the therapy, the rate of cholesterol esterification increased gradually and attained at the end of the study a value exceeding by 50% the initial level. The final fractional turnover rate nearly equalled that characteristic for the control group of healthy subjects, in spite of the fact that the concentration of plasma cholesterol in the diseased subjects was higher by 50–100%. Triglyceride concentration decreased only transitorily in the course of the therapy with etiroxate. It is concluded that etiroxate is likely to normalize the rate of cholesterol turnover in the endogenous pool.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Hess R.
        Evaluation of drugs active against experimental atherosclerosis.
        in: Advances in Lipid Research. Vol. 2. Academic Press, New York, London1964: 381
        • Abrams J.J.
        • Grundy S.M.
        Cholesterol metabolism in hypothyroidism in man.
        J. Lipid Res. 1981; 22: 323
        • Starr P.
        Atherosclerosis, hypothyroidism and thyroid hormone therapy.
        in: Advances in Lipid Research. Vol. 16. Academic Press, New York, San Francisco, London1978: 345
        • Lageder H.
        • Irsigler K.
        Reduction of serum lipids by means of etiroxate (Liponorm® ).
        Atherosclerosis. 1975; 22: 473
        • Glomset J.A.
        • Wright J.L.
        Some properties of cholesterol esterifying enzyme in human plasma.
        Biochim. Biophys. Acta. 1964; 89: 266
        • Vondra K.
        • Válek J.
        • Dobiášová M.
        • Honzák R.
        Type II hyperlipoproteinaemia treated with etiroxate.
        Čas. Lek. Čes. 1979; 118: 1251
        • Franey J.R.
        • Amádor E.
        Serum cholesterol measurement based on ethanol extraction and ferric chloride-sulphuric acid.
        Clin. Chim. Acta. 1968; 21: 255
        • Marcel Y.
        • Vezina X.
        A method for the determination of the initial rate of reaction of lecithin: cholesterol acyltransferase in human plasma.
        Biochim. Biophys. Acta. 1973; 306: 497
        • Grafnetter D.
        A simplified estimation of triglycerides for diagnosis of hyperlipoproteinaemia.
        Vnitřni Lek. 1973; 19: 808
        • Fellin R.
        • Pagnan A.
        Electrophoresis of human serum lipoproteins on agarose-gel.
        in: Advances in Experimental Medicine and Biology. Vol. 38. Plenum Press, New York, London1973: 259-271
        • Dobiášová M.
        • Kopecks J.
        • Živný K.
        Lecithin: cholesterol acyltransferase determination.
        Čas. Lek. Čes. 1978; 117: 1394
        • Dobiášová M.
        • Vondra K.
        • Karen P.
        Basal lecithin: cholesterol acyltransferase activity in healthy subjects.
        Čas. Lek. Čes. 1978; 117: 1530
        • Dobiášová M.
        • Vondra K.
        Lecithin: cholesterol acyltransferase as a possible diagnostic tool in ischemic heart disease.
        Scand. J. Clin. Lab. Invest. 1978; 38: 129
        • Strisower B.
        • Gofman J.W.
        • Galioni E.F.
        • Rubinger J.H.
        • Pouteau J.
        • Guzvich P.
        Effect of desiccated thyroid substance on serum lipoproteins and serum cholesterol.
        Lancet. 1957; i: 120
      1. Dobiášová M., Vitek, V. and Kopecks J., TThe effect of etiroxate on LCAT and some enzymes of energetic metabolism, Physiol. Bohemoslov., In press.

        • Simon J.B.
        Red cell lipids in liver disease—Relationship to serum lipids and to lecithin-cholesterol acyltransferase.
        J. Lab. Clin. Med. 1971; 77: 891
        • Jansen W.
        • Egge H.
        • Murawski U.
        • Blumchen G.
        LCAT activity in patients with ischemic heart disease.
        in: 19th International Conference on the Biochemistry of Lipids, Paris, France1976
        • Dobiášová M.
        • Stříbná J.
        • Vondra K.
        Basal lecithin-cholesterol acyltransferase activity in patients with hypertension.
        Čas. Lek. Čes. 1979; 118: 579
        • Dobiášová M.
        • Kuhn E.
        • Djubeková E.
        • Vondra K.
        • Brodan V.
        Sleep deprivation effect on lecithin: cholesterol acyltransferase basal activity and on plasma levels of triglycerides and cholesterol.
        Čas. Lek. Čes. 1979; 118: 727
        • Saier E.L.
        • Nordstrand E.
        • Juwes M.W.
        • Hartsock J.R.
        The ratio of free to esterified cholesterol in serum.
        Amer. J. Clin. Path. 1979; 71: 83
        • Weisweiler P.
        • Schwandt P.
        Effects of etiroxate on low density and high density lipoproteins in hypercholesterolemic patients.
        Atherosclerosis. 1981; 39: 45
        • Beaumont J.-L.
        • Cooper G.R.
        • Carlson L.A.
        • Fejfar Z.
        • Fredrickson D.S.
        • Strasser T.
        Classification of hyperlipoproteinemias and hyperlipidemias.
        Bull. Wld Hlth Org. 1970; 43: 891
        • Tata J.R.
        • Ernster L.
        • Linderberg O.
        Control of basal metabolic rate by thyroid hormones and cellular function.
        Nature (Lond.). 1962; 193: 1058
        • Russell R.L.
        • Soler-Argilaga C.
        • Heimberg M.
        Stimulation of serum lecithin-cholesterol acyltransferase activity by phenobarbital in the rat.
        Life Sci. 1976; 19: 1347