Reduction of exercise-induced ST segment depressions following long-term serum lipid lowering by drugs in hyperlipoproteinaemia

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      The effect of serum lipid-lowering drug treatment for a mean time of more than 5 years on the development of ischaemic ECG response to exercise has been studied in 34 asymptomatic subjects with hyperlipoproteinaemia. Seventy percent of the subjects had ischaemic exercise response at a first test. After treatment 10 subjects had improved and 9 deteriorated. Improvement of the ischaemic response was related to a decrease in low density lipoprotein (LDL) cholesterol as the only parameter significantly differing from those who developed a more marked ischaemia. For confirmation, controlled study of the influence of serum lipid lowering on the ischaemic exercise ECG response are necessary. The present finding indicates that marked lowering of LDL cholesterol might decrease the ischaemic response seen in hyperlipidaemia.


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