Serum malanodialdehyde (TBA reactive substance) levels in cigarette smokers

      This paper is only available as a PDF. To read, Please Download here.


      Serum malanodialdehyde (MDA) levels in 40 smokers and 23 non-smokers belonging to different age groups were estimated. The MDA levels were high in smokers of all age groups having a history of smoking for less than 10 years. MDA levels, however, were not elevated in smokers with a history of smoking for more than 10 years. These results are discussed and are interpreted as suggestive that MDA might alter the LDL and lead to deposition of cholesterol in arterial wall macrophages explaining thereby the risk of ischaemic heart disease in cigarette smokers.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


      1. Timmis G.C. Cardiovascular Review. Grune and Stratton Inc, Orlando1985: 9-29
        • Kruth H.S.
        Sub-endothelial accumulation of unesterified cholesterol. An early event in atherosclerotic lesion development.
        Atherosclerosis. 1985; 57: 337
        • Connor W.E.
        The relationship of hyperlipoproteinaemia to atherosclerosis: The decisive role of dietary cholesterol and fat.
        in: Scanu A.M. The Biochemistry of Atherosclerosis. Marcel Dekker Inc, New York1979: 371
        • Brown M.S.
        • Goldstein J.L.
        Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis.
        Ann. Rev. Biochem. 1983; 52: 223
        • Goldstein J.L.
        • Ho Y.K.
        • Brown M.S.
        • Innerarity T.Y.
        • Mahley R.W.
        Cholesterol ester accumulation in macrophages resulting from receptor-mediated uptake and degradation of hypercholesterolemic canine beta-very low density lipoproteins.
        J. Biol. Chem. 1980; 255: 1839
        • Koster I.F.
        • Beimond P.
        • Momtfoot A.
        • Stam H.
        The involvement of free radicals in pathological conditions.
        Life Chem. Rep. 1986; 3: 323
        • Pryor W.A.
        • Tamura M.
        • Dolley M.M.
        • Bremovic P.
        • Hales B.J.
        • Church D.F.
        Reactive oxy-radicals from cigarette smoke and their physiological effects.
        in: Oxy-Radicals and Their Scavenger Systems, Vol. 2 (Cellular and Medical Aspects). Elsevier, Amsterdam1983: 185
        • Geokas M.C.
        Ethanol and the pancreas.
        Med. Clin. N. Amer. 1984; 68: 57
        • Nadiger H.A.
        • Sara Rani M.
        • Chandrakala M.V.
        • Kulkarni D.D.
        Malonyldialdehyde levels in different organs of rats subjected to acute alcohol toxicity.
        Ind. J. Clin. Biochem. 1986; 1: 133
        • Shaw S.
        • Jayatilleke E.
        • Ross W.A.
        Ethanol induced lipid peroxidation: Potentiation by chronic alcohol feeding and attenuation by methionine.
        J. Lab. Clin. Med. 1981; 98: 417
        • Wendell G.
        • Thurman R.G.
        Effect of ethanol concentration on rates of ethanol elimination in normal and alcohol treated rats in vivo.
        Biochem. Pharmacol. 1979; 28: 273
        • Wald E.B.
        • Cohn P.E.
        Petersdorf Adams Braunwald Isselbacher Martin Wilson Harrison's Principle of Int. Medicine X. McGraw-Hill Int. Book Comp, New York1983