Effects of gammalinolenic acid on plasma lipoproteins and apolipoproteins

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      Nineteen hypercholesterolemic patients (10 without and 9 with hypertriglyceridemia) were given evening primrose oil rich in gammalinolenic acid (GLA, 18: 3n - 6), in a placebo controlled cross-over design, over 16 weeks (8 + 8 weeks), with safflower oil as the placebo. During supplementation with evening primrose oil, dihomogammalinolenic acid (20: 3n - 6) increased in plasma lipids and red blood cells, and in subjects without hypertriglyceridemia there was a significant decrease in low density lipoprotein-cholesterol and plasma apolipoprotein B compared with the levels observed during safflower oil administration. Our results confirmed that evening primrose oil is effective in lowering low density lipoprotein in hypercholesterolemic patients.



      VLDL (very low density lipoprotein (d < 1.006 g/ml)), LDL (low density lipoprotein (1.006 g/ml < d < 1.063 g/ml)), HDL2 (high density lipoprotein2 (1.063 g/ml < d < 1.125 g/ml)), HDL2 infranatant (high density lipoprotein2 infranatant (d > 1.125 g/ml))
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