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Effects of gammalinolenic acid on plasma lipoproteins and apolipoproteins

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      Abstract

      Nineteen hypercholesterolemic patients (10 without and 9 with hypertriglyceridemia) were given evening primrose oil rich in gammalinolenic acid (GLA, 18: 3n - 6), in a placebo controlled cross-over design, over 16 weeks (8 + 8 weeks), with safflower oil as the placebo. During supplementation with evening primrose oil, dihomogammalinolenic acid (20: 3n - 6) increased in plasma lipids and red blood cells, and in subjects without hypertriglyceridemia there was a significant decrease in low density lipoprotein-cholesterol and plasma apolipoprotein B compared with the levels observed during safflower oil administration. Our results confirmed that evening primrose oil is effective in lowering low density lipoprotein in hypercholesterolemic patients.

      Keywords

      Abbreviations:

      VLDL (very low density lipoprotein (d < 1.006 g/ml)), LDL (low density lipoprotein (1.006 g/ml < d < 1.063 g/ml)), HDL2 (high density lipoprotein2 (1.063 g/ml < d < 1.125 g/ml)), HDL2 infranatant (high density lipoprotein2 infranatant (d > 1.125 g/ml))
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