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Abstract
Although it has been reported that bezafibrate influences carbohydrate metabolism,
this possibility has never been properly evaluated in a controlled clinical trial.
In this study we attempted to evaluate the effects of bezafibrate on plasma lipoproteins,
glucose tolerance, insulin secretion and peripheral insulin sensitivity in a group
of hypertriglyceridemic patients with and without diabetes. Sixteen hyperlipidemic
patients (10 males and 6 females) participated in the study. Eight had type IIB and
8 type IV hyperlipoproteinemia; 6 of them also had non-insulin dependent diabetes
mellitus. The study was performed according to a double blind, crossover design: after
1 month wash-out period in which patients were on diet alone, they underwent, in a
random order, a period of placebo therapy and another period in which they received
a single daily dose of a long-acting bezafibrate preparation (400 mg) administered
in the evening. Each treatment lasted 2 months. Total plasma and VLDL triglyceride
concentrations were consistently reduced by bezafibrate (−46%, P < 0.001; and −50%, P<0.001). Total and VLDL-cholesterol were also reduced by bezafibrate. The effects
of bezafibrate on lipoproteins were similar in diabetic and non-diabetic subjects.
Bezafibrate treatment did not influence fasting blood glucose concentration, glucose
tolerance, peripheral insulin sensitivity or insulin secretion. In conclusion, the
results of this controlled trial clearly indicate that bezafibrate can be successfully
employed to lower plasma lipid levels in patients with non-insulin dependent diabetes
mellitus and hyperlipidemia.
Keywords
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Article info
Publication history
Accepted:
October 12,
1988
Received in revised form:
October 10,
1988
Received:
April 12,
1988
Identification
Copyright
© 1989 Published by Elsevier Inc.
