Advertisement

High density lipoprotein concentrations after cessation of smoking: the importance of alterations in diet

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Cessation of smoking is followed by a rapid rise in plasma HDL concentrations. An earlier study has demonstrated a significant relationship between the increase in HDL concentrations and spontaneous changes in food intake, specifically an increased fat intake. In this investigation we have dissociated the effects of cessation of smoking as such from those of dietary alterations by monitoring plasma lipid and lipoprotein concentrations after cessation of smoking in 12 subjects whose diet was kept constant during an initial 2-week control period and during 2 weeks following cessation of smoking. Under these conditions plasma HDL-cholesterol levels did not increase significantly (1.01 ± 0.26 mmol/1 (mean ± SD) before and 1.04 ± 0.27 mmol/1 after cessation of smoking). Similarly, no significant alterations were recorded for other plasma lipid or lipoprotein concentrations. Activities of lipoprotein lipase and hepatic lipase were unchanged throughout the study. These results suggest that the marked rise in HDL concentrations after stopping smoking is largely related to spontaneous changes in dietary habits which occur upon cessation of smoking.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Hammond E.C.
        Smoking in relation to the death rate of one million men and women.
        Natl. Cancer Monogr. 1966; 19: 127
        • Criqui M.H.
        • Wallace R.B.
        • Heiss G.
        • Mishkel M.
        • Schonfeld G.
        • Jones G.T.L.
        Cigarette smoking and plasma high density lipoprotein cholesterol: the Lipid Research Clinics Program Prevalence Study.
        Circulation. 1980; 62: 70
        • Garrison R.J.
        • Kannel W.B.
        • Feinleib M.
        • Castelli W.P.
        • McNamara P.M.
        • Padgett S.J.
        Cigarette smoking and HDL cholesterol. The Framingham offspring study.
        Atherosclerosis. 1978; 30: 17
        • Stubbe L.
        • Eskilsson J.
        • Nilsson-Ehle P.
        HDL concentrations increase after stopping smoking.
        Br. Med. J. 1982; 284: 1511
        • Danielsson B.
        • Ekman R.
        • Fex G.
        • Johansson B.G.
        • Kristensson H.
        • Nilsson-Ehle P.
        • Wadstein J.
        Changes in plasma high density lipoproteins in chronic male alcoholics during and after abuse.
        Scand. J. Clin. Lab. Invest. 1978; 38: 113
        • Roeschlau P.
        • Bernt E.
        • Gruber W.
        Enzymatische Bestimmungen des Gesamtcholesterin im Serum.
        Z. Klin. Chem. 1974; 12: 226
        • Wahlefeld A.W.
        Triglyceride determination after enzymatic hydrolysis.
        in: Bergmeyer H.U. Methods of Enzymatic Analysis. 2nd edn. Verlag Chemie, Weinheim and Academic Press, New York1974
        • Schriewer H.
        • Jung G.
        • Emke F.
        • Assman G.
        An economical assay for HDL phosphatidyl choline.
        J. Clin. Chem. Clin. Biochem. 1983; 21: 611
        • Laurell C.B.
        Electroinununoassay.
        Scand. J. Clin. Lab. Invest. 1972; 29: 21
        • Friedewald W.T.
        • Levy R.I.
        • Fredrickson D.S.
        Estimation of the concentration of low density lipoprotein cholesterol without use of the preparative ultracentrifuge.
        Clin. Chem. 1972; 18: 499
        • Nilsson-Ehle P.
        • Ekman R.
        Rapid, simple and specific assays for lipoprotein lipase and hepatic lipase.
        Artery. 1977; 2: 194
        • Rabkin S.W.
        Effect of cigarette smoking cessation on risk factors for coronary atherosclerosis. A controlled clinical trial.
        Atherosclerosis. 1984; 53: 173
        • Stamford B.A.
        • Matter S.
        • Fell R.D.
        • Papanek P.
        Effects of smoking cessation on weight gain, metabolic rate, caloric consumption, and blood lipids.
        Am. J. Clin. Nutr. 1986; 43: 486
        • Fortman S.P.
        • Haskell W.L.
        • Williams P.T.
        Changes in plasma high density lipoprotein cholesterol after changes in cigarette use.
        Am. J. Epidemiol. 1986; 124: 706
        • Dalasso H.M.
        • James W.P.T.
        The role of smoking in regulation of energy balance.
        Int. J. Obesity. 1984; 8: 365