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Abstract
Elevated plasma homocysteine and lipid levels are risk factors for atherosclerosis.
The plasma levels of homocysteine, determined in acid hydrolyzates of plasma, were
found to be correlated with total cholesterol (r = 0.47, P < 0.001), triglycerides (r = 0.40, P < 0.01), and body mass index (r = 0.42, P < 0.01) in 52 males, aged 30–60. A group of 12 male survivors of acute myocardial
infarction was given pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin
for 21 days. The plasma concentrations of homocysteine and α-amino adipic acid declined
to 68% (P < 0.001) and 57% (P < 0.001) of the pretreatment values, and the cholesterol, triglycerides, and LDL
apo B declined to 79% (P < 0.001), 68% (P < 0.01), and 63% (P < 0.001) of the pretreatment values, respectively. The results suggest a new strategy
for control of the metabolic abnormalities in atherosclerosis through the use of naturally
occurring, non-toxic nutrients which minimize homocysteine accumulation.
Keywords
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Article info
Publication history
Accepted:
June 29,
1988
Received in revised form:
June 20,
1988
Received:
January 11,
1988
Footnotes
☆Supported by National Grant KPBR MZ 09 from the Polish Ministry of Health.
Identification
Copyright
© 1989 Published by Elsevier Inc.
