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Abstract
Elevated plasma homocysteine and lipid levels are risk factors for atherosclerosis.
The plasma levels of homocysteine, determined in acid hydrolyzates of plasma, were
found to be correlated with total cholesterol (r = 0.47, P < 0.001), triglycerides (r = 0.40, P < 0.01), and body mass index (r = 0.42, P < 0.01) in 52 males, aged 30–60. A group of 12 male survivors of acute myocardial
infarction was given pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin
for 21 days. The plasma concentrations of homocysteine and α-amino adipic acid declined
to 68% (P < 0.001) and 57% (P < 0.001) of the pretreatment values, and the cholesterol, triglycerides, and LDL
apo B declined to 79% (P < 0.001), 68% (P < 0.01), and 63% (P < 0.001) of the pretreatment values, respectively. The results suggest a new strategy
for control of the metabolic abnormalities in atherosclerosis through the use of naturally
occurring, non-toxic nutrients which minimize homocysteine accumulation.
Keywords
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References
- The pathogenesis of coronary artery disease: A possible role for methionine metabolism.J. Clin. Invest. 1976; 57: 1079
- Moderate homocysteinemia — a possible risk factor for arteriosclerosic cerebrovascular disease.Stroke. 1984; 15: 1012
- Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease.New Engl. J. Med. 1985; 313: 709
- Methionine intolerance: a possible risk factor for coronary artery disease.J. Amer. Coll. Cardiol. 1985; 6: 725
- Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease.J. Clin. Invest. 1986; 77: 1482
- Homocysteine content of plasma proteins in ischemic heart disease.Atherosclerosis. 1988; 69: 109
- The role of homocysteine in the pathogenesis of arteriosclerosis.in: 2nd edition. Proc. First Congr. Hung. Pharmacol. Soc.2. 1973: 287
- Homocysteine theory of arteriosclerosis: development and current status.Atheroscler. Rev. 1983; 11: 157
- Effect of vitamin B6 depletion in adult man on the excretion of cystathionine and other methionine metabolites.J. Nutr. 1970; 100: 110
- Homocysteinemia due to folate deficiency.Metabolism. 1987; 5: 458
- Atheromatous changes in aorta, carotid and coronary arteries of choline deficient rats.in: 2nd edition. Proc. Soc. Exp. Biol. Med.81. 1952: 384
- B2-dependent methionine biosynthesis.in: Dolphin D. B2. John Wiley, New York1982: 307
- Reduction of dehydroascorbic acid by thiols in the presence of biocatalytic substances: a polarographic study.Int. J. Vitam. Nutr. Res. 1982; 52: 159
- Action of vitamin P like compounds on lysosomal fragility in hypercholesterolemia: implication of ascorbic acid and its metabolites.Acta Vitaminol. Enzymol. 1984; 6: 97
- Homocysteine metabolism in scurvy, growth and arteriosclerosis.Nature. 1971; 231: 391
- The interaction of human plasma glycosaminoglycans with plasma lipoproteins.J. Biol. Chem. 1975; 250: 5386
- Recent advances in molecular pathology. Carbohydrate-protein macromolecules and arterial wall integrity — A role in atherosclerosis.Exp. Mol. Pathol. 1984; 41: 267
- Serum apolipoprotein B determination by radial immunodiffusion (RID) in clinical practice.Pol. J. Human Nutr. Metabol. 1983; 10: 59
- Biochemistry of the Amino Acids.in: 2nd edition. Academic Press, New York1965: 757
- Growth promotion by homocysteic acid.Science. 1976; 192: 372
- The reaction of homocysteine with aldehydes — An explanation of the collagen defects in homocystinuria.Clin. Chim. Acta. 1973; 45: 215
- A collagen defect in homocystinuria.J. Clin. Invest. 1973; 52: 2571
- Serum triglycerides, cholesterol, low density lipoprotein apo B and high density lipoprotein cholesterol serofractions after moderate body weight loss.Die Nahrung. 1984; 28: 327
- Platelet function in hyperlipoproteinemia.New Engl. J. Med. 1974; 290: 434
- Homocysteine thiolactone, N-homocysteine thiolactonyl retinamide and platelet aggregation.Res. Commun. Chem. Pathol. Pharmacol. 1987; 56: 349
Article Info
Publication History
Accepted:
June 29,
1988
Received in revised form:
June 20,
1988
Received:
January 11,
1988
Footnotes
☆Supported by National Grant KPBR MZ 09 from the Polish Ministry of Health.
Identification
Copyright
© 1989 Published by Elsevier Inc.
