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Relationships between serum testosterone, fasting insulin and lipoprotein levels among elderly men

  • Sigismond Deutscher
    Correspondence
    Correspondence to: Sigismond Deutscher, M.D., Medical Service, VA Medical Center Pittsburgh, University Drive C, Pittsburgh, PA 15240, U.S.A.
    Affiliations
    Veterans Administration Medical Center and Departments of Medicine, Community Medicine and Pathology, University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA U.S.A.
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  • Margaret W. Bates
    Affiliations
    Veterans Administration Medical Center and Departments of Medicine, Community Medicine and Pathology, University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA U.S.A.
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  • Myrven J. Caines
    Affiliations
    Veterans Administration Medical Center and Departments of Medicine, Community Medicine and Pathology, University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA U.S.A.
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  • Ronald E. LaPorte
    Affiliations
    Veterans Administration Medical Center and Departments of Medicine, Community Medicine and Pathology, University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA U.S.A.
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  • Anthony Puntereri
    Affiliations
    Veterans Administration Medical Center and Departments of Medicine, Community Medicine and Pathology, University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA U.S.A.
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  • Vincent C. Arena
    Affiliations
    Veterans Administration Medical Center and Departments of Medicine, Community Medicine and Pathology, University of Pittsburgh School of Medicine, and Department of Epidemiology, Graduate School of Public Health, Pittsburgh, PA U.S.A.
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      Abstract

      We have previously reported the existence of an association between endogenous male sex hormone and lipoprotein levels in elderly men confined to a nursing home. In a further attempt to elucidate the significance of the association mentioned, we studied the relationship existing in that population between serum testosterone and fasting insulin levels, and between fasting insulin level and lipoprotein pattern. The data were analysed by means of stepwise multiple regression analyses. Serum testosterone and fasting insulin were found to be strongly correlated; this is consistent with the notion that androgen secretion affects directly circulating insulin level. But no independent relationship was demonstrable between fasting insulin and the three lipid-lipoprotein categories studied, namely total serum cholesterol, triglyceride and HDL-cholesterol, suggesting that in this particular population, the effect of male sex hormones upon lipoproteins is not mediated through insulin. Together, these various observations support the belief that androgen secretion affects significantly CAD risk factor levels in elderly men.

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