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Abstract
The aortic endothelium of inherited cataract rats (ICR), which spontaneously develop
cataracts and neutrophilia, was examined by scanning electron microscopy using silver
nitrate staining and pressure fixation. In ICR aged 4 weeks, the luminal surface of
the aorta was similar to that in Wistar rats from which they had been derived. However,
8 weeks after birth, endothelial cells were upraised and partially detached from an
underlying tissue. At 16 weeks, morphological changes exhibited by such detaching
cells were more evident than at 8 weeks and fibrin was seen to be adhering to the
surface of these cells; no platelet involvement was noted, however. Oral administration
of DL-a-tocopheryl acetate for 2 weeks resulted in a reduction in the extent of endothelial
injury and the luminal surface of the aorta became similar to that seen in 4- or 8-week-old
animals. We found that the number of age-associated spontaneous injuries occurring
in the aortic endothelium of ICR could be reduced by tocopherol administration.
Keywords
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References
- Response to injury and atherogenesis.Am. J. Pathol. 1977; 86: 675
- Neutrophil oxidants inactivate alpha-l-protease inhibitor and promote PMN-mediated detachment of cultured endothelium.Arteriosclerosis. 1986; 6: 332
- Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.J. Clin. Invest. 1978; 61: 1161
- Role of hydrogen peroxide in neutrophilmediated destruction of cultured endothelial cells.J. Clin. Invest. 1981; 68: 714
- Neutrophil-mediated endothelial injury in vitro. Mechanisms of cell detachment.J. Clin. Invest. 1981; 68: 1381
- A new strain of rat with an inherited cataract.Experientia. 1983; 39: 909
- A new rat model for dermatitis: constitutional abnormalities evidenced by hematological and serum protein determinations.Exp. Anim. 1986; 35: 139
- Occurrence of early thymus atrophy and the skin lesions observed in the cataractous rats of ICR/d-strain.J. Kansai Med. Univ. 1984; 36 (in Japanese): 575
- The study of host defense in the cataractous rats of ICR-strain.Nippon Taishitugakkai Zasshi. 1986; 50 (in Japanese): 9
- Simple and rapid method for the diagnosis of chronic granulomatous disease, measuring hydrogen peroxide and superoxide anions released from leukocytes in whole blood.Clin. Chim. Acta. 1979; 92: 329
- Endothelial regeneration, III. Time course of intimal changes after small defined injury to rat aortic endothelium.Lab. Invest. 1981; 44: 301
- The effect of hypercholesterolemia on aortic endothelium studied en face.Atherosclerosis. 1975; 22: 335
- Quantitative SEM analysis of injury to the endothelium of rabbit aorta and carotid artery during experimental atherosclerosis.Atherosclerosis. 1982; 41: 141
- The cellular pathology of experimental hypertension, IV. Evidence for increased vascular permeability.Am. J. Pathol. 1969; 54: 187
- Light and scanning electron microscopic and immunohistochemical studies on permeability of hypertensive rat mesenteric arteries.Acta Pathol. Jpn. 1985; 35: 1057
- Ultrastructural demonstration of NADPH oxidase activity in Kupffer and endothelial cells using an isolated liver perfusion system — Comparison between ICR/d-strain and Jcl:Wistar-strain rats.Acta Histochem. Cytochem. 1984; 17: 649
Article info
Publication history
Accepted:
August 8,
1988
Received in revised form:
August 3,
1988
Received:
April 20,
1987
Footnotes
☆This work was supported by a Grant-in-Aid for the Encouragement of Young Scientist (Project No. 62771993), from the Japanese Ministry of Education.
Identification
Copyright
© 1989 Published by Elsevier Inc.