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Freshwater fish diet affects lipid composition, deformability and aggregation properties of erythrocytes

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      Abstract

      The effect of a 12-week diet of freshwater fish on fatty acid composition of the erythrocyte membrane, RBC deformability and artificial aggregation behavior of erythrocytes was studied in 20 healthy subjects. A different quantity of meals containing fish per week (control group, 1.5 and 3.8 fish meals per week) resulted in an increased content of n − 3 polyunsaturated fatty acids. The whole cell deformability of single erythrocytes characterized by a modified micropipette technique (capillary-rigidometer) was significantly increased dependent on fish intake. The parameter of entry time for cell deformability had a negative correlation with the Math Eq ratio of fatty acids. No change was observed in MCV and MCHC of erythrocytes after the diet. The artificial aggregation behavior of washed erythrocytes in a suspension medium of low ionic strength and reduced pH was decreased depending on the number of fish meals eaten. The present results suggest that a relatively small shift in the profile of the polyunsaturated fatty acids causes changes in the viscoelastic properties of the erythrocyte membrane and in the artificially-induced aggregation of erythrocytes.

      Keywords

      Abbreviations:

      RBC (red blood cells), MCV (mean corpuscular volume), MCHC (mean corpuscular hemoglobin content)
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