Advertisement

Soy cotyledon fiber products reduce plasma lipids

  • Grace S. Lo
    Correspondence
    Correspondence to: Dr. Grace S. Lo, Protein Technologies International, Checkerboard Square, St. Louis, MO 63164, U.S.A.. Telephone: (314) 982-3035.
    Affiliations
    Protein Technologies International, Checkerboard Square, St. Louis, MO 63164 U.S.A.
    Search for articles by this author
  • Thomas G. Cole
    Affiliations
    Lipid Research Center, Department of Internal Medicine, Washington University, St. Louis, MO 63110 U.S.A.
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      This study was designed to test the hypocholesterolemic effect of soy cotyledon fiber in the diet as ready-to-eat cereal and white bread, in free-living subjects having mildly elevated, fasting plasma total cholesterol levels. Twenty subjects completed a 15-week double-blind crossover design protocol. It consisted of two 6-week test periods and a 3-week rest period in between the two test periods. Subjects were randomly allotted to two test groups with comparable initial cholesterol levels. Fifteen grams of dietary fiber per day from soy cotyledon fiber was supplemented in three divided doses (equivalent to 20 g Fibrim® soy fiber/day). Dietary records were kept for 3 consecutive days for each test period and were calculated using a computer program. Subjects were asked to maintain their normal eating habits and body weights throughout the 15-week protocol. There were no significant differences in nutrient intake between the two supplementation periods based on 3 day dietary records, except that the amount of fiber intake was significantly higher when soy cotyledon fiber was supplemented (24 g vs. 13 g/day). Soy cotyledon fiber supplementation did not produce visible intolerance. Body weights and blood pressures were not significantly affected. Soy cotyledon fiber supplementation significantly lowered plasma total cholesterol by 7.7% (from 240 to 222 mg/dl, P < 0.01) and LDL-cholesterol by 7.4% (from 159 to 145 mg/dl, P < 0.04). Plasma HDL-cholesterol and total triglycerides were not significantly affected. Placebo supplementation insignificantly lowered plasma total cholesterol by 1.5% (P < 0.44) and LDL-cholesterol by 5% (P < 0.15), but significantly increased plasma total triglycerides after 6 weeks of supplementation (+11.5%, P < 0.01). There was a significant difference in plasma total triglyceride levels between placebo and soy cotyledon fiber supplementations (+ 11.5% vs. −4.2%, P < 0.02). Results from this study agree with our previous observations that soy cotyledon fiber supplementation significantly lowers plasma total and LDL-cholesterol in people having mildly elevated plasma cholesterol levels.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Anderson J.W.
        • Tietyen-Clark J.
        Dietary fiber: hyperlipidemia, hypertension, and coronary heart disease.
        Amer. J. Gastroenterol. 1986; 81: 907
        • Lo G.S.
        • Goldberg A.P.
        • Lim A.
        • Grundhauser J.J.
        • Anderson C.
        • Schonfeld G.
        Soy fiber improves lipid and carbohydrate metabolism in primary hyperlipidemic subjects.
        Atherosclerosis. 1986; 62: 239
        • Shorey R.L.
        • Day P.J.
        • Willis R.A.
        • Lo G.S.
        • Steinke F.H.
        Effects of soybean polysaccharide on plasma lipids.
        J. Am. Diet. Assoc. 1985; 85: 1461
        • Lo G.S.
        • Evans R.H.
        • Phillips K.S.
        • Dahlgren R.R.
        • Steinke F.H.
        Effect of soy fiber and soy protein on cholesterol metabolism and atherosclerosis in rabbits.
        Atherosclerosis. 1987; 64: 47
        • Aspinall G.O.
        • Begbie R.
        • McKay J.E.
        Polysaccharide components of soybeans.
        Cereal Sci. Today. 1967; 12: 224
        • Aspinall G.O.
        Chemistry of soybean carbohydrate.
        in: Soybean Utilization Alternatives, a symposium sponsored by the Center for Alternative Crops and Products. University of Minnesota, February 16–18, 1988: 117-129
      1. JAOAC. 1985; 68 (43.A14–43.A20): 399
        • Englyst H.N.
        • Cummings J.H.
        Improved method for measurement of dietary fiber as non-starch polysaccharide in plant foods.
        AOAC. 1988; 71: 808
        • Warnick G.R.
        • Albers J.J.
        A comprehensive evaluation of the Heparin-Manganese precipitation procedure for estimating high density lipoprotein cholesterol.
        J. Lipid Res. 1978; 19: 65
        • Friedewald W.T.
        • Levy R.I.
        • Fredrickson D.S.
        Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative centrifuge.
        Clin. Chem. 1972; 18: 499
      2. Version 5 Edition. SAS User's Guide: Statistics. SAS Institute, Inc, Cary, NC1985
        • Tsai A.C.
        • Vinik A.I.
        • Lasichak A.
        • Lo G.S.
        Effects of soy polysaccharide on postprandial plasma glucose, insulin, glucagon, pancreatic polypeptide, somatostatin, and triglyceride in obese diabetic patients.
        Am. J. Clin. Nutr. 1987; 45: 596
        • Anderson J.W.
        • Story L.
        • Sieling B.
        • Chen W.L.
        • Petro M.S.
        • Story J.
        Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic men.
        Am. J. Clin. Nutr. 1984; 40: 1146
        • Kay R.M.
        • Judd P.A.
        • Truswell A.S.
        The effect of pectin on serum cholesterol.
        Am. J. Clin. Nutr. 1978; 31: 562
        • Jenkins D.J.A.
        • Reynolds D.
        • Slavin B.
        • Leeds A.R.
        • Jenkins A.L.
        • Jepson E.M.
        Dietary fiber and blood lipids. Treatment of hypercholesterolemia with guar crispbread.
        Am. J. Clin. Nutr. 1980; 33: 575
        • Bosello O.
        • Cominacini L.
        • Zocca L.
        • Garbin U.
        • Fenari F.
        • Davoli A.
        Effects of guar gum on plasma lipoproteins and apolipoproteins C-II and C-III in patients affected by familial combined hyperlipoproteinemia.
        Am. J. Clin. Nutr. 1984; 40: 1165
        • Gatti E.
        • Catenazzo G.
        • Comisasca E.
        • Torri A.
        • Denegri E.
        • Sirtori C.R.
        Effect of guar-enriched pasta in the treatment of diabetes and hyperlipidemia.
        Ann. Nutr. Metab. 1984; 28: 1
        • Aro A.
        • Uusitupa M.
        • Voutilainen E.
        • Korhonen T.
        Effects of guar gum in male subjects with hypercholesterolemia.
        Am. J. Clin. Nutr. 1984; 39: 911
        • Danielsson A.
        • Ek B.
        • Nyklin H.
        • Steen L.
        Effect of long term treatment with hydrophilic colloid on serum lipids.
        Acta Hepato-Gastroenterol. 1979; 26: 148
        • Fagerberg S.-E.
        The effect of a bulk laxative (Metamucil) on fasting blood glucose, serum lipids and other variables in constipated patients with non-insulin dependent adult diabetes.
        Curr. Therap. Res. 1982; 31: 166
        • Abraham Z.D.
        • Mehta T.
        Three-week psyllium-husk supplementation: effect on plasma cholesterol concentrations, fecal steroid excretion and carbohydrate absorption in man.
        Am. J. Clin. Nutr. 1988; 47: 67
        • Van Horn L.V.
        • Lin K.
        • Parker D.
        • Emidy L.
        • Liao Y.
        • Pan in.H.
        • Giumetti D.
        • Hewitt J.
        • Stamler J.
        Serum lipid response to oat product intake with a fat-modified diet.
        J. Am. Diet. Assoc. 1986; 86: 759
        • Kirby R.W.
        • Anderson J.W.
        • Sieling B.
        Oat-bran intake selectively lowers serum low-density lipoprotein cholesterol concentration of hypercholesterolemic men.
        Am. J. Clin. Nutr. 1981; 34: 824
        • Gold K.V.
        • Davison D.M.
        Oat bran as a cholesterolreducing dietary adjunct in a young, healthy population.
        West. J. Med. 1988; 148: 299