Human aortic proteoglycans of subjects from districts of high and low prevalence of atherosclerosis in China

      This paper is only available as a PDF. To read, Please Download here.


      The contents of three species of proteoglycans (PGs), heparan sulfate PG(HSPG), chondroitin sulfate PG(CSPG) and dermatan sulfate chondoitin sulfate PG(DSCSPG), in human thoracic aortas of subjects from districts of high (Beijing, in North China) and low (Nanning, in South China) prevalence of atherosclerosis in China were quantitated. Higher aortic HSPG and DSCSPG (but lower DS) in samples from Nanning than those from,Beijing might be implicated in the lower prevalence of atherosclerosis in the former.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Beaty N.B.
        • Mello J.
        Extracellular mammalian polysaccharides: Glycosaminoglycans and proteoglycans.
        J. Chromatogr. 1987; 418: 187
        • Kuettner K.E.
        • Kimura J.H.
        Proteoglycans: an overview.
        J. Cell. Biochem. 1985; 27: 327
        • Poole A.R.
        Proteoglycans in health and disease: Structures and functions.
        Biochem. J. 1986; 236: 1
        • Wight T.N.
        Vessel proteoglycans and thrombogenesis.
        in: 2nd edn. Progress in Hemostasis and thrombosis. Vol. 5. Grune and Stratton, New York1980: 1
        • Salisburg B.G.J.
        • Wagner W.D.
        Isolation and preliminary characterization of proteoglycans dissociatively extracted from human aorta.
        J. Biol. Chem. 1981; 256: 8050
        • Chang Y.S.
        • Cong X.F.
        • Zhu Z.M.
        • Zhang C.L.
        • Wang Z.
        Proteoglycans of human aorta 1. Extraction, isolation and preliminary characterization of dissociatively extracted proteoglycans.
        Acta Biochim. Biophys. Sin. 1987; 19: 253
        • Berenson G.S.
        • Radhakrishnamurthy B.
        • Srinivasan S.R.
        • Vijayagopal P.
        • Dalferes E.R.
        Proteoglycans and potential mechanisms related to atherosclerosis.
        Ann. N.Y. Acad. Sci. 1985; 454: 69
        • Wight T.N.
        Extracellular matrix changes in atherosclerosis.
        in: Camilleri J.-P. Berry C.L. Fiessinger J.-N. Bariety J. Diseases of the Arterial Wall. Springer-Verlag, Heidelberg1989: 185
        • Camejo G.
        • Acquatella H.
        • Lalaguna F.
        The interaction of low density lipoproteins with arterial proteoglycans: an additional risk factor?.
        Atherosclerosis. 1980; 36: 55
        • Hurt E.
        • Camejo G.
        Effect of Arterial proteoglycans on the interaction of LDL with human monocyte-derived macrophages.
        Atherosclerosis. 1987; 67: 115
        • Chang Y.S.
        • Cong X.F.
        • Zhang C.L.
        • Zhu Z.M.
        Proteoglycans of human aorta 11. Proteoglycans in normal and atherosclerotic lesions.
        Chin. J. Biochem. Biophys. 1988; 20: 73
        • Tao S.C.
        • Huang Z.D.
        • Wu X.G.
        • Zhou B.F.
        • Xiao Z.K.
        • Hao J.S.
        • Li X.H.
        • Cen R.C.
        • Rao X.X.
        CHD and its risk factors in the People's Republic of China.
        Int. J. Epidemiol. 1989; 18: S159
        • Authors
        A coordination group in China. A pathological survey of atherosclerotic lesions of coronary artery and aorta in China.
        Pathol. Res. Pract. 1985; 180: 457
        • Bitter T.
        • Muir H.M.
        A modified uronic acid carbazole reaction.
        Anal. Biochem. 1962; 4: 330
        • Shively J.E.
        • Conrad H.E.
        Formation of anhydrosugar in the chemical depolymerization of heparin.
        Biochemistry. 1976; 15: 3932
        • Lohmander L.S.
        • De Luca S.
        • Nilsson B.
        • Hascall V.C.
        • Caputo C.B.
        • Kimura J.H.
        • Heinegard D.
        Oligosaccharides on proteoglycans from the swarm rat chondrosarcoma.
        J. Biol. Chem. 1980; 255: 6084
        • Carlson D.M.
        Structures and immunochemical properties of oligosaccharides isolated from pig submaxillary mucins.
        J. Biol. Chem. 1968; 243: 616
        • Saito H.
        • Yamagata T.
        • Suzuki S.
        Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates.
        J. Biol. Chem. 1968; 243: 1536
        • Wessler E.
        Analytical and preparative separation of acidic glycosaminoglycans by electrophoresis in barium acetate.
        Anal. Biochem. 1968; 26: 439
        • Marcum J.A.
        • Reilly C.F.
        • Rosenberg R.D.
        Heparan sulfate species and blood vessel wall function.
        in: Wight T.N. Mecham R.P. Biology of Proteoglycans. Academic Press, Inc, New York1987: 301
        • Vijayagopal P.
        • Srinivasan S.R.
        • Radhakrishnamurthy B.
        • Berenson G.S.
        Hemostatic properties and serum lipoprotein binding of a heparan sulfate proteoglycan from bovine aorta.
        Biochim. Biophys. Acta. 1983; 758: 70
        • Simada K.
        • Ozawa T.
        Evidence that cell surface heparan sulfate is involved in the high affinity thrombin binding to cultured porcine aortic endothelial cells.
        J. Clin. Invest. 1985; 75: 1308
        • Wight T.N.
        • Lark M.W.
        • Kinsella M.G.
        Blood vessel proteoglycans.
        in: Wight T.N. Mecham R.P. Biology of Proteoglycans. Academic Press, Inc, New York1987: 267
        • Fransson L.-A.
        • Carlstedt I.
        • Cöster L.
        • Malmström A.
        The functions of the heparan sulfate proteoglycans.
        in: Evered D. Whelan J. Ciba Foundation Symposium 124, Functions of the Proteoglycans. John Wiley and Sons, New York, Chichester1986: 125
        • Winterbourne D.J.
        • Salisbury J.G.
        Heparan sulfate is a potent inhibitor of DNA synthesis in vitro.
        Biochem. Biophys. Res. Commun. 1981; 101: 30
        • Schmidt A.
        • Vischer P.
        • Volker W.
        • Buddecke E.
        Proteoheparan sulfate of arterial smooth muscle cells as endogenous proliferation regulator.
        in: Hauss W.H. Wissler R.W. Bauch H.-J. Modern Aspect of the Pathogenesis of Arteriosclerosis, 5th Münster Int Arterioscler. Symp. Westdeutscher Verlag, Germany1989: 121
        • Hollmann J.
        • Schmidt A.
        • Bassewitz D.-B.
        • Buddecke E.
        Relationship of sulfated glycosaminiglycans and cholesterol content in normal and arteriosclerotic human aorta.
        Arteriosclerosis. 1989; 9: 154
        • Steele R.H
        • Wagner W.D.
        • Rowe H.A.
        • Edwards I.J.
        Artery wall derived proteoglycan-plasma lipoprotein interaction: lipoprotein binding properties of extracted proteoglycans.
        Atherosclerosis. 1987; 65: 51
        • Srinivasan S.R.
        • Dolan P.
        • Radhakrishnamurthy B.
        • Berenson G.S.
        Isolation of lipoprotein-acid mucopolysaccharide complexes from fatty streaks of human aortas.
        Artherosclerosis. 1972; 16: 95
        • Srinivasan S.R.
        • Radhakrishnamurthy B.
        • Dalferes Jr., E.R.
        • Berenson G.S.
        Collagenase-solubilized lipoprotein-glycosaminoglycan complexes of human aortic fibrous plaque lesions.
        Atherosclerosis. 1979; 34: 105
        • Srinivasan S.R.
        • Lopez S.A.
        • Radhakrishnamurthy B.
        • Berenson G.S.
        Complexing of serum pre-B and B-lipoproteins and acid mucopolysaccharides.
        Atherosclerosis. 1970; 12: 321
        • Zhu Z.M.
        • Chang Y.S.
        The interaction of human serum lipoprotein with glycosaminoglycans and human aortic proteoglycans.
        Chin. Biochem. J. 1989; 5: 61
        • Salisbury B.G.J.
        • Falcone D.J.
        • Minick C.R.
        Insoluble low density lipoprotein-proteoglycan complexes enhance cholesteryl ester accumulation in macrophages.
        Am. J. Pathol. 1985; 120: 6