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Abstract
It has been shown that triglyceride levels are one of the determinants of factor VII
levels. In this study we have simultaneously evaluated, in a group of 102 healthy
individuals, the different forms of factor VII, namely factor VII mass, factor VII
coagulant activity, activated factor VII double-chain form and factor VII-phospholipid
complex, in relation to triglyceridaemia. The data showed a highly significant correlation
of factor VII mass, factor VII coagulant activity and factor VII-phospholipid complex
with triglycerides. No correlation was observed between the activated factor VII double-chain
form and triglycerides. These data, together with analysis of the linear and orthogonal
regression slopes, suggest that increase of plasma factor VII coagulant activity as
a function of plasma triglyceride levels is attributable to an increase in both mass
and activity of factor VII and that the increase in activity is dependent on an increase
of factor VII-phospholipid complex rather than activated factor VII double-chain form.
The ratio between the slopes of the regression straight line of factor VII mass and
factor VII-phospholipid complex in relation to triglycerides was 2.23 (95% confidence
limits 1.74–2.50), thus indicating that the contribution of factor VII mass is prevalent
over that of the factor VII-phospholipid complex.
Keywords
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References
- Purification and properties of human coagulation factor VII.J. Biol. Chem. 1980; 255: 1242
- Tissue factor and hemostasis.Blood. 1988; 71: 1
- The coagulation factor VII in pregnancy.Br. J. Haematol. 1984; 56: 233
- A novel form of factor VII in plasma from men at risk for cardiovascular disease.Br. J. Haematol. 1985; 61: 315
- Haemostatic function and cardiovascular death: early results of a prospective study.Lancet,. 1980; 1: 1050
- Haemostatic function and ischemic heart disease: principal results of the Northwick Park Heart Study.Lancet. 1986; 2: 533
- Increased activity of vitamin K-dependent clotting factors in human hyperlipoproteinemia. Association with cholesterol and triglyceride levels.Thromb. Haemostas. 1977; 38: 465
- Interrelationship of plasma triglyceride and coagulant factor VII levels in normotriglyceridemic hypercholesterolemia.Atherosclerosis. 1989; 75: 129
- Factor VII coagulant activity is strongly associated with the plasma concentration of large lipoprotein particles in middle-aged men.Atherosclerosis. 1989; 76: 203
- Factor VII activation and menopausal status.Thromb. Res. 1990; 57: 227
- Thrombosis and ischaemic heart disease.Br. Heart J. 1985; 53: 473
- Phospholipase C sensitive FVII activity and FVII antigen in hypertriglyceridemia.Nouv. Rev. Fr. Hematol. 1989; 31: 13
- Further evidence that activated factor VII is related to plasma lipid.Br. J. Haematol. 1985; 61: 177
- Assay of factor VII activity by two techniques: evidence for increased conversion of VII to a-VIIa in hyperlipidaemia, with possible implications for ischaemic heart disease.Br. J. Haematol. 1985; 59: 249
- Factor VII-phospholipid complex in male survivors of acute myocardial infarction.Acta Med. Scand. 1987; 222: 111
- Cold-induced contact surface activation of the prothrombin time in whole blood.Blood. 1982; 59: 38
- Factor VII in an industrial population.Br. J. Haematol. 1974; 28: 381
- An enzyme immunoassay (elisa) for the quantitation of human factor VII.Thromb. Haemostas. 1986; 56: 250
- The activity state of factor VII in plasma: two pathways for the cold promoted activation of factor VII.Br. J. Haematol. 1986; 62: 367
- Factor VII clotting assay: influence of different thromboplastins and factor VII-deficient plasmas.Thromb. Haemostas. 1991; 65: 160
- The theory of reference values: statistical treatment of collected reference values, determination of reference limits.J. Clin. Chem. Clin. Biochem. 1983; 21: 749
- A new form of coagulation factor VII in plasma.Scand. J. Haematol. 1986; 36: 430
- Phospholipase C-sensitive factor VII activity in normal pregnancy.Acta Obstet. Gynecol. Scand. 1990; 69: 111
- Clotting factor VII during pregnancy, delivery and puerperium.Br. J. Obstet. Gynaecol. 1986; 93: 17
- Coagulation factors and hyperlipidaemia.Curr. Opinion Lipidol. 1991; 2: 266
Article info
Publication history
Accepted:
October 23,
1992
Received in revised form:
October 14,
1992
Received:
March 19,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.