Advertisement

Lipoprotein(a) is not associated with coronary heart disease in the elderly: cross-sectional data from the Dubbo study

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Lipoprotein(a) (Lp(a)) may be an independent risk factor for cardiovascular disease. We have examined Lp(a) concentration in 1202 males and 1512 females, aged 60 years and older, who were participants in an ongoing prospective study of cardiovascular disease in the elderly. This report relates to cross-sectional data at study entry. Median Lp(a) concentration was significantly higher in females than in males (P < 0.001), but did not vary with age. Lp(a) concentration rank was significantly correlated with total (r = 0.16, P < 0.001) and LDL cholesterol (r = 0.19, P < 0.001), but this relationship disappeared after adjustment of LDL cholesterol for Lp(a) cholesterol content. Twenty-four percent of males and 17% of females had prevalent coronary heart disease (CHD) at study entry based on non-invasive criteria. Median Lp(a) concentration was slightly higher in those subjects with CHD, compared with those without CHD, but the difference was not statistically significant (P > 0.20). In a multiple logistic model, the following variables were independent predictors of CHD in this elderly population: age, hypertension (males only), family history of CHD, HDL cholesterol and triglycerides (females only), but not total cholesterol or Lp(a). These relationships were similar whether or not the model included Lp(a) concentration. The findings do require confirmation in the prospective study now in progress.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Atherosclerosis
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Utermann G.
        The mysteries of lipoprotein(a).
        Science. 1989; 246: 904
        • Dahlen G.H.
        • Guyton J.R.
        • Attar M.
        • et al.
        Association of levels of lipoprotein(a), plasma lipids and other lipoproteins with coronary artery disease documented by angiography.
        Circulation. 1986; 74: 758
        • Rhoads G.G.
        • Dahlen G.
        • Berg K.
        • et al.
        Lp(a) lipoprotein as a risk factor for myocardial infarction.
        JAMA. 1986; 256: 2540
        • Murai A.
        • Miyahara T.
        • Fujimato N.
        • et al.
        Lp(a) lipoprotein as a risk factor for coronary artery disease and cerebral infarction.
        Atherosclerosis. 1986; 59: 199
        • Rosengren A.
        • Wilhelmsen L.
        • Eriksson E.
        • et al.
        Lipoprotein(a) and coronary heart disease: a prospective case-control study in a general population sample of middle aged men.
        Br. Med. J. 1990; 301: 1248
        • Jauhiainen M.
        • Koskinen P.
        • Ehnholm C.
        • et al.
        Lipoprotein(a) and coronary heart disease risk: a nested case-control study of the Helsinki Heart Study participants.
        Atherosclerosis. 1991; 89: 59
        • Utermann G.
        • Menzel H.J.
        • Kraft H.G.P
        • et al.
        Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentration in plasma.
        J. Clin. Invest. 1987; 80: 458
        • Rath M.
        • Niendorf A.
        • Reblin T.
        • et al.
        Detection and quantification of lipoprotein(a) in the arterial wall of 107 coronary bypass patients.
        Arteriosclerosis. 1989; 9: 579
        • Simons L.A.
        • McCallum J.
        • Friedlander Y.
        • et al.
        Dubbo study of the elderly: sociological and cardiovascular risk factors at entry.
        Aust. N.Z. J. Med. 1991; 21: 701
        • Simons L.A.
        • Friedlander Y.
        • McCallum J.
        • et al.
        The Dubbo study of the health of elderly: correlates of coronary heart disease at study entry.
        J. Am. Geriatr. Soc. 1991; 39: 584
        • Rose G.A.
        • Blackburn H.
        • Gillum R.F.
        • Prineas R.J.
        Cardiovascular Survey Methods.
        2nd Edn. WHO, Geneva1982
        • Allain C.C.
        • Poon L.C.
        • Chan C.S.G.
        • et al.
        Enzymatic determination of total serum cholesterol.
        Clin. Chem. 1974; 20: 470
        • Bucolo G.
        • David H.
        Quantitative determination of serum triglycerides by the use of enzymes.
        Clin. Chem. 1973; 19: 476
        • Burstein M.
        • Scholnick H.R.
        • Morphin R.
        Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions.
        J. Lipid. Res.,. 1970; 11: 583
        • Leitersdorf E.
        • Friedlander Y.
        • Bard J.-M.
        • et al.
        Diverse effect of ethnicity on plasma lipoprotein(a) levels in heterozygote patients with familial hypercholesterolemia.
        J. Lipid Res. 1991; 32: 1513
        • Craig W.Y.
        • Ledue T.B.
        The effects of long term storage on serum Lp(a) levels.
        Atherosclerosis. 1992; 93: 261
        • Mbewu A.D.
        • Durrington P.N.
        Lipoprotein(a) structure, properties and possible involvement in thrombogenesis and atherogenesis.
        Atherosclerosis. 1990; 85: 1
        • Utermann G.
        • Hoppichler F.
        • Dietlinger H.
        • et al.
        Defects in the LDL receptor gene affect Lp(a) lipoprotein levels: multiplicative interaction of two gene loci associated with premature atherosclerosis.
        in: Proc. Natl. Acad. Sci. USA. 86. 1989: 4171
        • Wiklund O.
        • Angelin B.
        • Olofsson S.O.
        • et al.
        Apolipoprotein(a) and ischaemic heart disease in familial hypercholesterolaemia.
        Lancet. 1990; 335: 1360
        • Mbewu A.
        • Bhatnadar D.
        • Mackness M.
        • et al.
        Serum lipoprotein(a) level in patients with familial hypercholesterolaemia, their relatives and control populations.
        Clin. Sci. 1990; 79: 138