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Full length article| Volume 102, ISSUE 1, P37-49, August 01, 1993

Effect of coarctation on matrix content of experimental aortic atherosclerosis: relation to location, plaque size and blood pressure

DOI:https://doi.org/10.1016/0021-9150(93)90082-6
Effect of coarctation on matrix content of experimental aortic atherosclerosis: relation to location, plaque size and blood pressure
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      Abstract

      Cynomolgus monkeys were fed an atherogenic diet for 6 months following surgically produced high-grade (n = 10) or mild (n = 16) mid-thoracic aortic coarctation. A diet-control (DC) group (n = 13) was fed the diet without coarctation. High-grade coarctation (HGC) resulted in 74.1% ± 8.3% stenosis by aortography prior to sacrifice and was associated with systolic brachial blood pressures of 143.3 ± 26.0 mmHg and gradients across the stenoses of 36.8 ± 23.6 mmHg. Mild coarctation (MC) resulted in stenoses of 50.9% ± 12.9%, brachial systolic pressures of 119.4 ± 25.7 and gradients of 12.5 ± 15.2 mm Hg (P < 0.01, P = 0.03 and P < 0.005, respectively, compared with HGC). When total plaque cross-sectional area exceeded 0.8 mmz, the entire arterial circumference was usually involved. HGC resulted in complete sparing or minimal plaque formation in sections distal to the stenoses compared with proximal sections (P < 0.001). There were no significant differences between MC and DC animals in plaque location or size. Matrix content increased with plaque area regardless of degree of stenosis or sampling level (P < 0.01), but lesions with more than 75% matrix content were more numerous in distal than in proximal sections despite their smaller size. The number of plaques with greater than 75% matrix content was increased proximal to HGC (P < 0.04). Thus, distal location and plaque size were independent determinants of plaque matrix content and matrix content was increased proximal to HGC regardless of plaque size. Attempts to evaluate effects of various regimens and interventions on plaque composition need to take location and plaque size, as well as blood pressure differences, into account.

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      References

        • Vesselinovitch D.
        • Wissler R.W.
        • Schaffner T.J.
        • Borensztajn T.
        The effects of various diets on atherogenesis in rhesus monkeys.
        Atherosclerosis. 1980; 35: 189
        • Constantinides P.
        Experimental Atherosclerosis.
        in: Elsevier Publishers, Amsterdam1965: 27
        • Constantinides P.
        Experimental Atherosclerosis.
        in: Elsevier Publishers, Amsterdam1965: 41
        • Armstrong M.L.
        • Warner E.D.
        • Connor W.E.
        Regression of coronary atheromatosis in rhesus monkeys.
        Circ. Res. 1970; 27: 59
        • Bomberger R.A.
        • Zarins C.K.
        • Taylor K.E.
        • Glagov S.
        Effect of hypotension on atherogenesis and aortic wall composition.
        J. Surg. Res. 1980; 28: 402
        • Zarins C.K.
        • Bomberger R.A.
        • Taylor K.E.
        • Glagov S.
        Artery stenosis inhibits regression of diet-induced atherosclerosis.
        Surgery. 1980; 88: 86
        • Bomberger R.A.
        • Zarins C.K.
        • Glagov S.
        Subcritical arterial stenosis enhances distal atherosclerosis.
        J. Surg. Res. 1981; 30: 205
        • Ku D.N.
        • Giddens D.P.
        • Zarins C.K.
        • Glagov S.
        Pulsatile flow and atherosclerosis in the human carotid bifurcation.
        Arteriosclerosis. 1985; 5: 293
        • Beere P.A.
        • Glagov S.
        • Zarins C.K.
        Retarding effect of lowered heart rate on coronary atherosclerosis.
        Science. 1984; 226: 180
        • Beere P.A.
        • Glagov S.
        • Zarins C.K.
        Experimental atherosclerosis at the carotid bifurcation of the cynomolgus monkey: localization, compensatory enlargement and the sparing effect of heart rate.
        Arterioscler. Thromb. 1992; 12: 1245
        • Lyon R.T.
        • Runyon-Hass A.
        • Davis H.R.
        • Glagov S.
        • Zarins C.K.
        Protection from atherosclerotic lesion formation by reduction of artery wall motion.
        J. Vasc. Surg. 1987; 5: 59
        • Taylor K.E.
        • Glagov S.
        • Zarins C.K.
        Preservation and structural adaptation of endothelium over experimental foam cell lesions. Quantitative ultrastructural study.
        Arteriosclerosis. 1989; 9: 881
        • Vesselinovitch D.
        • Wissler R.W.
        • Harris L.
        • Lusk L.
        The relationship between lipoprotein levels and xanthomas during progression and regression of atherosclerosis.
        Atherosclerosis. 1980; 36: 351
      14. Guide for the Care and Use of Laboratory Animals. 2nd Edn. DHEW Publication, No. 78-23. National Institutes of Health, Bethesda, MD1978
      15. 2nd Edn. The University of Chicago Manual for the Care and Use of Laboratory Animals, El-1-F3-3, FF-02, FF-07. University of Chicago, Chicago, IL1988
        • Glagov S.
        • Grande J.
        • Vesselinovitch D.
        • Zarins C.K.
        Quantitation of cells and fibers in histologic sections of arterial wall: advantages of contour tracing on a digitizing plate.
        in: McDonald T.F. Chandler A.B. Connective tissues in Arterial and Pulmonary Disease. Springer-Verlag, New York1981: 57
        • Louis T.A.
        Analysis of categorical data: exact tests and log-linear models.
        in: Mike V. Stanley K. Statistics in Medical Research: Methods and Issues, with Applications in Cancer Research. John Wiley, New York1982: 409
        • McGill Jr., H.C.
        • Frank M.H.
        • Geer J.C.
        Aortic lesions in hypertensive monkeys.
        Arch. Pathol. 1961; 71: 96
        • Haust M.D.
        • More R.H.
        Significance of the smooth muscle cell in atherogenesis.
        in: Evolution of the Atherosclerotic Plaque. University of Chicago, Chicago, IL1964: 51
        • Stout L.C.
        • Thorpe L.W.
        Histology of normal aortas in birds with emphasis on intimal thickening.
        Atherosclerosis. 1980; 36: 545
        • Guthaner D.F.
        • Wexter L.
        • Harell G.
        CT demonstration of cardiac structures.
        Am. J. Roentgenol. 1979; 133: 75
        • Aronberg D.J.
        • Glazer H.S.
        • Madsen K.
        • Sagel S.S.
        Normal thoracic aortic diameters by computed tomography.
        J. Comput. Assist. Tomogr. 1984; 8: 247
        • Harkness M.L.R.
        • Harkness R.D.
        • McDonald D.A.
        The collagen and elastin content of the arterial wall in the dog.
        in: 2nd Edn. Proc. R. Soc. (London) Ser. B. 146. 1957: 541
        • Wolinsky H.
        • Glagov S.
        Comparison of abdominal and thoracic aortic medial structure in mammals: deviation of man from the usual pattern.
        Circ. Res. 1969; 25: 677
        • Maier N.
        • Haimovici H.
        Metabolism of arterial tissue: oxidative capacity of intact arterial tissue.
        in: 2nd Edn. Proc. Soc. Exp. Biol. Med.95. 1957: 425
        • Maier N.
        • Haimovici H.
        Oxidative activity of aortic tissue of man, the rabbit and the dog with special reference to succinic dehydrogenase and cytochrome oxidase.
        Am. J. Physiol. 1958; 195: 476
        • Rand J.H.
        • Badimon L.
        • Gordon R.E.
        • Uson R.R.
        • Fuster V.
        Distribution of von Willebrand factor in porcine intima varies with blood vessel type and location.
        Arteriosclerosis. 1987; 7: 287
        • Wu Q.Y.
        • Drouet L.
        • Carrier J.L.
        • Rothschild C.
        • Berard M.
        • Rousault C.
        • Caen J.P.
        • Meyer D.
        Differential distribution of von Willebrand factor in endothe lial cells: comparison between normal pigs and pigs with von Willebrand disease.
        Arteriosclerosis. 1987; 7: 47
        • Kowala M.C.
        • Cuénoud H.F.
        • Joris I.
        • Majno G.
        Cellular changes during hypertension: a quantitative study of the rat aorta.
        Exp. Mol. Pathol. 1986; 45: 323
        • Koletsky S.
        • Roland C.
        • Rivera-Velez J.M.
        Rapid acceleration of atherosclerosis in hypertensive rats on high fat diet.
        Exp. Mol. Pathol. 1968; 9: 322
        • Hollander W.
        • Madoff I.
        • Paddock J.
        • Kirkpatrick B.
        Aggravation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta.
        Circ. Res. 1976; 38: II-63
        • Clowes A.W.
        • Clowes M.M.
        The influence of hypertension on injury-induced myointimal thickening.
        Surgery. 1980; 88: 254
        • Hollander W.
        • Kramsch D.M.
        • Farmelant M.
        • Madoff I.M.
        Arterial wall metabolism in experimental hypertension of coarctation of the aorta of short duration.
        J. Clin. Invest. 1968; 47: 1221
        • Leung D.Y.M.
        • Glagov S.
        • Mathews M.B.
        Cyclic stretching stimulates synthesis of matrix components by arterial smooth muscle cells in vitro.
        Science. 1976; 191: 475
        • Grande J.P.
        • Glagov S.
        • Bates S.R.
        • Horwitz A.L.
        • Mathews M.B.
        Effect of normolipemic and hyperlipemic serum on biosynthetic response to cyclic stretching of aortic smooth muscle cells.
        Arteriosclerosis. 1989; 9: 446
        • Bassiouny H.S.
        • Davis H.
        • Masawa N.
        • Gewertz B.L.
        • Glagov S.
        • Zarins C.K.
        Critical carotid stenoses: morphologic and chemical similarity between symptomatic and asymptomatic plaques.
        J. Vase. Surg. 1989; 9: 202
        • Haust M.D.
        • More R.H.
        • Movat H.Z.
        The role of smooth muscle cells in the fibrogenesis of arteriosclerosis.
        Am. J. Pathol. 1960; 37: 377
        • Imai H.
        • Lee K.T.
        • Pastori S.
        • Panlilio E.
        • Florentin R.
        • Thomas W.A.
        Atherosclerosis in rabbits: architectural and subcellular alterations of smooth muscle cells of aortas in response to hyperlipemia.
        Exp. Mol. Pathol. 1966; 5: 273
        • Ross R.
        • Klebanoff S.J.
        The smooth muscle cell: I. In vivo synthesis of connective tissue proteins.
        J. Cell Biol. 1971; 50: 159
        • Ross R.
        The smooth muscle cell: II. Growth of smooth muscle in culture and formation of elastic fibers.
        J. Cell Biol. 1971; 50: 172
        • Wissler R.W.
        The arterial medial cell, smooth muscle or multifunctional mesenchyme?.
        J. Atheroscler. Res. 1968; 8: 201
        • Duncan Jr., L.E.
        • Buck K.
        • Lynch A.
        The effect of pressure and stretching on the passage of labeled albumin into canine aortic wall.
        J. Atheroscler. Res. 1965; 5: 69
        • Wiener J.
        • Lattes R.G.
        • Meltzer B.G.
        • Spiro D.
        The cellular pathology of experimental hypertension. IV. Evidence for increased vascular permeability.
        Am. J. Pathol. 1969; 54: 187
        • Wolinsky H.
        Response of the rat aortic media to hypertension: morphological and chemical studies.
        Circ. Res. 1970; 26: 507
        • Still W.J.
        The early effect of hypertension on the aortic intima of the rat: an elctron microscopic study.
        Am. J. Pathol. 1967; 51: 721
        • Esterly J.A.
        • Glagov S.
        Altered permeability of the renal artery of the hypertensive rat: an electron microscopic study.
        Am. J. Pathol. 1963; 43: 619

      Article Info

      Publication History

      Accepted: March 30, 1993
      Received in revised form: January 15, 1993
      Received: August 31, 1992

      Identification

      DOI: https://doi.org/10.1016/0021-9150(93)90082-6

      Copyright

      © 1993 Published by Elsevier Inc.

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