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Abstract
Previously we have shown that incubation of heparinized blood with a low dose of lipopolysaccharides
(5 ng/ml) resulted in a 60% higher generation of TxB2 in the blood of young men as compared with that of young women. In the present study,
we investigated a group consisting of 38 healthy men and 38 healthy postmenopausal
women aged 50–73 years with no drug use and no known chronic disease. In contrast
to our earlier observation that young men produce more TxB2 than young women, no significant
difference was observed between the men and women when all the participants above
50 years of age were included (5.7 ± 0.6 ng/1 for men versus 5.2 ± 0.7 ng/1 for women).
However, a strong correlation was found with simple regression analysis when increasing
TxB2 generation was compared with years after menopause (P < 0.0001). No such correlation was observed for increasing age of men and their TxB2
production. The LPS stimulation system of whole blood was also used to evaluate the
production of tumor necrosis factor (TNF-α) in older people. Men were found to generate
60% more TNF-α than women, but no correlation was found between increasing age of
women and TNF-a production as observed with TxB2. Risk factors such as SDS-cholesterol, fibrinogen and factor VII were the same in
men and women, whereas total cholesterol was higher in women than in men (P < 0.05). Since TxA2 is known to be a mediator of atherosclerosic-induced lesions and TNF-α is a well-established
indicator of inflammatory reactions, we propose that the reduced production of TxB2 and TNF-α in women in our model system may partially explain the lower incidence
of atherosclerosis in women as compared with men, and the phenomenon of increased
incidence of this disease after menopause.
Keywords
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Article info
Publication history
Accepted:
April 6,
1993
Received in revised form:
March 24,
1993
Received:
June 23,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.