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Research Article| Volume 101, ISSUE 1, P43-49, June 1993

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Marathon runners presented lower serum cholesteryl ester transfer activity than sedentary subjects

DOI:https://doi.org/10.1016/0021-9150(93)90100-9
Marathon runners presented lower serum cholesteryl ester transfer activity than sedentary subjects
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      Abstract

      Acute exercise promotes raised HDL cholesterol concentrations by lipolysis stimulation, but this effect is insufficient to explain the more permanent HDL increases seen during regular exercise. During training periods in a group of marathon runners, we measured lipid transfer protein I (LTP-I)-mediated cholesteryl ester transfer activity (CETA) and its relationship to their HDL concentrations. Runners of both sexes showed significantly lower CETA values than those of sedentary controls. Male runners also had significantly lower serum concentrations of triglyceride, VLDL cholesterol and apolipoprotein B, and significantly higher concentrations of HDL cholesterol and apolipoprotein A-I than male controls. Results indicate that regular practice of aerobic exercise promotes modifications of lipoprotein metabolism related not only to lipolysis, but also to lower CETA. Such modifications are associated with reduced risk of atherosclerosis.

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      References

        • Godberg L.
        • Elliot D.C.
        The effect of exercise on lipid metabolism in men and women.
        Sports Med. 1987; 4: 307
        • Haskell W.L.
        Exercise-induced changes in plasma lipids and lipoproteins.
        Prev. Med. 1984; 13: 23
        • Weintraub M.S.
        • Rosen Y.
        • Otto R.
        • Eisenberg S.
        • Breslow J.L.
        Physical exercise conditioning in the absence of weight loss reduces fasting and post-prandial triglyceride rich lipoprotein levels.
        Circulation. 1989; 79: 1007
        • Krauss R.M.
        Exercise, lipoproteins and coronary artery disease.
        Circulation. 1989; 79: 1143
        • Lokey E.A.
        • Tran Z.V.
        Effects of exercise training on serum lipid and lipoprotein concentrations in women: a meta-analysis.
        Int. J. Sports Med. 1989; 10: 424
        • Nakamura N.
        • Uzawa H.
        • Haeda H.
        • Inomoto T.
        Physical fitness, its contribution to serum high density lipoprotein.
        Atherosclerosis. 1983; 48: 173
        • Haskell W.L.
        • Taylor H.L.
        • Wood P.D.
        • Schrott H.
        • Heiss G.
        Strenuous physical activity, treadmill exercise test performance and plasma high density lipoprotein cholesterol: the lipid research program prevalence study.
        Circulation. 1980; 62: 53
        • Sutherland W.
        • Woodhouse S.
        Physical activity and plasma lipid concentrations in men.
        Atherosclerosis. 1980; 37: 285
        • Schaefer E.J.
        • Foster D.M.
        • Zech L.A.
        • Lindgren F.T.
        • Brewer H.B.
        • Levy R.I.
        The effects of estrogen administration on plasma lipoprotein metabolism in premenopausal females.
        J. Clin. Endocrinol. Metab. 1983; 32: 428
        • Castelli W.P.
        • Doyle J.T.
        • Gordon T.
        • Hamries C.G.
        • Hjortland M.C.
        • Hulley S.B.
        • Kagan A.
        • Zukel W.J.
        High density lipoprotein cholesterol and other lipids in coronary heart disease: The Cooperative Lipoprotein Phenotyping Study.
        Circulation. 1977; 55: 767
        • Sady S.P.
        • Thompson P.D.
        • Cullinane E.N.
        • Kantor M.A.
        • Domagala E.
        • Herbert P.M.
        Prolonged exercise augments plasma triglyceride clearance.
        J. Am. Med. Assoc. 1986; 256: 2552
        • Eisenberg S.
        High density lipoprotein metabolism.
        J. Lipid Res. 1986; 27: 361
        • Barter P.J.
        • Hopkin G.J.
        • Ha Y.C.
        The role of lipid transfer proteins in plasma lipoprotein metabolism.
        Am. Heart J. 1987; 113: 538
        • Tall A.R.
        Plasma lipid transfer proteins.
        J. Lipid Res. 1986; 27: 361
        • Tollefson J.H.
        • Liu A.
        • Albers J.J.
        Regulation of plasma lipid transfer by the high density lipoproteins.
        Am. J. Physiol. 1988; 255: E894
        • Son Y.C.
        • Zilversmit D.B.
        Increased lipid transfer activities in hyperlipidemic rabbit plasma.
        Arteriosclerosis. 1986; 6: 345
        • Morton R.E.
        • Zilversmit D.B.
        A plasma inhibitor of triglyceride and cholesteryl ester transfer activities.
        J. Biol. Chem. 1981; 256: 11992
        • Gambert P.
        • Bouzerand-Gambert C.
        • Athias A.
        • Farnier M.
        • Lallemant C.
        Human low density lipoprotein subfractions separated by gradient gel electro phoresis: composition, distribution, and alterations induced by cholesteryl ester transfer protein.
        J. Lipid Res. 1990; 31: 1199
        • Izzo C.
        • Grillo F.
        • Murador E.
        Improved method for determination of high-density lipoprotein cholesterol. Isolation of high-density lipoproteins by use of polyethylene glycol 6000.
        Clin. Chem. 1981; 27: 371
        • Morton R.E.
        Binding of plasma derived lipid transfer protein to lipoprotein substrates. The role of binding in the lipid transfer process.
        J. Biol. Chem. 1985; 260: 12593
        • Marcel Y.L.
        • McPherson R.
        • Hogue M.
        • Czarnecka H.
        • Zawadzki Z.
        • Weech P.K.
        • Whitlock M.E.
        • Tall A.R.
        • Milne R.W.
        Distribution and concentration of cho lesteryl ester transfer protein in plasma of normolipemic subjects.
        J. Clin. Invest. 1990; 85: 10
        • Speijer H.
        • Groener J.E.M.
        • Van Ramshort E.
        • Van Tol A.
        Different locations of cholesteryl ester transfer protein and phospholipid transfer protein activities in plasma.
        Atherosclerosis. 1991; 90: 159
        • Groener J.E.M.
        • Pelton R.W.
        • Kostner G.M.
        Improved estimation of cholesteryl ester transfer/exchange activity in serum or plasma.
        Clin. Chem. 1986; 32: 283
        • Tollefson J.H.
        • Albers J.J.
        Isolation, characterization, and assay of plasma lipid transfer proteins.
        Methods Enzymol. 1986; 129: 797
        • Yamashita S.
        • Hui D.Y.
        • Wetterau J.R.
        • Sprecher D.L.
        • Harmony J.A.K.
        • Sakai N.
        • Matsuzawa Y.
        • Tarui S.
        Characterization of plasma lipoproteins in patients heterozygous for human plasma cholesteryl ester transfer protein (CETP) deficiency: plasma CETP regulates highdensity lipoprotein concentration and composition.
        Metabolism. 1991; 40: 756
        • Morton R.E.
        Free cholesterol is a potent regulator of lipid transfer protein function.
        J. Biol. Chem. 1988; 263: 12235
        • Nishide T.
        • Tollefson J.H.
        • Albers J.J.
        Inhibition of lipid transfer by a unique high density lipoprotein subclass containing an inhibitor protein.
        J. Lipid Res. 1989; 30: 149
        • Quinet E.M.
        • Agellon L.B.
        • Kroon P.A.
        • Marcel Y.L.
        • Lee Y.C.
        • Whitlock M.E.
        • Tall A.R.
        Atherogenic diet increases cholesteryl ester transfer protein messenger RNA levels in rabbit liver.
        J. Clin. Invest. 1990; 85: 357
        • Groener J.E.M.
        • Jacobs D.M.
        • Van Rozen A.F.
        • Erkelens D.W.
        Diet, lipoproteins and cholesteryl ester transfer activity in hyperlipidaemic subjects.
        Clin. Nutr. 1985; 4: 35
        • Groener J.E.M.
        • Van Ramshorst E.M.
        • Katan M.B.
        • Mensink R.P.
        • Van Tol A.
        Diet-induced alteration in the activity of plasma lipid transfer protein in nor molipidemic human subjects.
        Atherosclerosis. 1991; 87: 221
        • Savolainen M.J.
        • Hannuksela M.
        • Seppanen S.
        • Kervinen K.
        • Kesainemi Y.A.
        Increased high-density lipoprotein cholesterol concentrations in alcoholics is related to low cholesteryl ester transfer protein activity.
        Eur. J. Clin. Invest. 1990; 20: 593
        • Dullaart R.P.F.
        • Hoogenberg K.
        • Groener J.E.M.
        • Dikkeschei L.D.
        • Erkelens D.W.
        • Doorenbos H.
        The activity of cholesteryl ester transfer protein is decreased in hypothyroidism: a possible contribution to alterations in high-density lipoproteins.
        Eur. J. Clin. Invest. 1990; 21: 581
        • Groener J.E.M.
        • Rozen A.J.V.
        • Erkelens D.W.
        Cholesterol ester transfer activity (CETA): localization and role in distribution of cholesteryl ester among lipoproteins in man.
        Atherosclerosis. 1984; 50: 261
        • Nakanishi T.
        • Tahara D.
        • Akazawa S.
        • Miyake S.
        • Nagataki S.
        Plasma lipid transfer activities in hyper highdensity lipoprotein cholesterolemic and healthy control subjects.
        Metabolism. 1990; 39: 225
        • Nagao N.
        • Imai Y.
        • Arie J.
        • Sawada Y.
        • Karatsu K.
        Comparison of serum apolipoproteins and lipoproteins in active and inactive males.
        J. Sports Med. 1988; 28: 67
        • Thompson P.D.
        • Cullinane E.M.
        • Sady S.P.
        • Flynn M.M.
        • Chenevert C.B.
        • Herbert P.N.
        High density lipoprotein metabolism in endurance athletes and sedentary men.
        Circulation. 1991; 84: 140
        • Lamon-Fava S.
        • Fisher E.C.
        • Nelson M.E.
        • Evans W.J.
        • Millar J.S.
        • Ordovas J.M.
        • Schaefer E.J.
        Effect of exercise and menstrual cycle status on plasma lipids, low den sity lipoprotein particle size and apolipoproteins.
        J. Clin. Endocrinol. Metab. 1989; 68: 17

      Article info

      Publication history

      Accepted: February 18, 1993
      Received in revised form: October 26, 1992
      Received: June 22, 1992

      Identification

      DOI: https://doi.org/10.1016/0021-9150(93)90100-9

      Copyright

      © 1993 Published by Elsevier Inc.

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