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Research Article| Volume 101, ISSUE 1, P111-115, June 1993

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Effects of physiological plasma insulin levels on glucose turnover parameters in familial hypercholesterolemia

DOI:https://doi.org/10.1016/0021-9150(93)90106-5
Effects of physiological plasma insulin levels on glucose turnover parameters in familial hypercholesterolemia
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      Abstract

      Eight young, non-obese patients with primary familial hypercholesterolemia (FH) and 8 healthy subjects matched for age, body mass index, lean body mass, plasma triglyceride and HDL-levels and arterial blood pressure were selected from a lipid clinic. Patients with FH had higher plasma LDL-cholesterol (8.3 ± 0.5 vs. 4.1 ± 0.2 mmol/l, P < 0.001) than controls but similar plasma triglyceride (1.15 ± 0.04 vs. 1.10 ± 0.02 mmol/l P = NS) levels. Both study groups were submitted to a euglycaemic hyperinsulinemic glucose clamp combined with simultaneous infusion of [3H]glucose to measure insulin action on whole-body glucose uptake and on hepatic glucose production. Two insulin infusion rates (0.15 mU/kg per min from 0 to 120 min and 0.30 mU/kg per min from 121 to 240 min) were used resulting in similar plasma insulin levels in both groups studied. Our results demonstrate that both whole-body glucose uptake and hepatic glucose output are similar in the fasting state as well as during insulin administration in both groups of subjects. We conclude that, in the absence of other causes of insulin resistance, isolated hypercholesterolemia is associated with normal sensitivity to insulin in both liver and peripheral tissues.

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      References

        • Rowe J.W.
        • Minaker K.L.
        • Pallotta J.
        • Flier J.S.
        Characterization of insulin resistance of aging.
        J. Clin. Invest. 1983; 71: 1581
        • Bonadonna R.
        • Groop L.
        • Kraemer N.
        • De Fronzo R.A.
        Obesity and insulin resistance in man: a dose response study.
        Metabolism. 1990; 39: 452
        • Reaven G.M.
        Role of insulin resistance in human disease.
        Diabetes. 1988; 37: 1595
        • Ferrannini E.
        • Buzzigoli G.
        • Bonadonna R.
        • Giorico M.A.
        • Oleggini M.
        • Graziadei L.
        • Pedrinelli R.
        • Brandi L.
        • Bevilacqua S.
        Insulin resistance in essential hypertension.
        N. Engl. J. Med. 1987; 317: 350
        • Reaven G.M.
        Insulin resistance and compensatory hyperinsulinemia: Role in hypertension, dyslipidemia and coronary heart disease.
        Am. Heart J. 1991; 121: 1283
        • Fontbonne A.M.
        • Eschwege E.M.
        Insulin and cardiovascular disease. Paris Prospective Study.
        Diabetes Care. 1991; 14: 461
        • Fuster V.
        • Bodimon L.
        • Bodimon J.L.
        • Chesebro J.H.
        The pathogenesis of coronary artery disease and the acute coronary syndromes.
        N. Engl. J. Med. 1992; 326: 242
        • Hsueh W.A.
        • Anderson P.W.
        Hypertension, the endothelial cell and the vascular complications of diabetes mellitus.
        Hypertension. 1992; 20: 253
        • Goldstein J.L.
        • Brown M.S.
        Familial hypercholesterolemia.
        in: Stanbury J.B. Wyngaarden J.B. Frerieckson D.S. Goldstein Brown M.S. The Metabolic Basis of Inherited diseases. 5th Edn. McGrawHill, 1983: 672-712
        • National Diabetes Data Group
        Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
        Diabetes. 1979; 28: 1039
        • Paolisso G.
        • Salvatore T.
        • Torella R.
        • Sgambato S.
        • Varricchio M.
        • D'Onofrio F.
        Metabolic effects of pulsatile insulininfusion in the elderly.
        Acta Endocrinol. 1990; 123: 19
        • Paolisso G.
        • Sgambato S.
        • Gentile S.
        • Memoli P.
        • Giugliano D.
        • Varricchio M.
        • D'Onofrio F.
        Advantageous metabolic effects of pulsatile insulin delivery in non-insulin dependent diabetes mellitus.
        J. Clin. Endocrinol. Metab. 1988; 67: 1005
        • De Long D.M.
        • De Long E.R.
        • Wood P.D.
        • Lippiel K.
        • Rifkind B.M.
        A comparison of methods for the estimation of plasma low and very low density lipoprotein cholesterol. The Lipid Research Clinics Prevalence Study.
        J. Am. Med. Assoc. 1986; 256: 2372
        • Segal K.R.
        • Van Loan M.
        • Fitzgerald P.I.
        • Hodgdon J.A.
        • Van Itallie E.
        Lean Body Mass estimation by bioelectrical impedance analysis: a four site crossvalidation study.
        Am. J. Clin. Nutr. 1988; 47: 7
        • Steele R.
        Influence of glucose loading and of injected insulin on hepatic glucose output.
        Ann. N.Y. Acad. Sci. 1959; 82: 420
        • Cobelli C.
        • Mari A.
        • Ferrannini E.
        Non steady state error analysis of Steele's model and development for glucose kinetics.
        Am. J. Physiol (Endocrinol. Metab.). 1987; 252: E679
        • Groop L.
        • Bonadonna R.
        • Shank M.
        • Petrides P.
        • De Fronzo R.A.
        Role of free fatty acids and insulin in determining free fatty acids and lipid oxidation in man.
        J. Clin. Invest. 1991; 87: 83
        • De Fronzo R.A.
        • Ferrannini E.
        Insulin resistance. A multi faced syndrome responsible for NIDDM, obesity, hypertension, dyslipidernia and atherosclerotic cardiovascular disease.
        Diabetes Care. 1991; 14: 173
        • Paolisso G.
        • Ferrannini E.
        • Sgambato S.
        • Varricchio M.
        • D'Onofrio F.
        Hyperinsulinemia in patients with primary hypercholesterolemia.
        J. Clin. Endocrinol. Metab. 1992; 75: 1409
        • Cordera R.
        • Bertolini S.
        • Andraghetti G.
        • Pistocchi G.
        • De Alessi M.
        • Gherzi R.
        Insulin binding on red cells of hypertriglyceridemic patients. Effect of low fat, low carbohydrate diet.
        Diabete Metab. 1985; 11: 137
        • Ferrannini E.
        • Haffner S.M.
        • Mitchel S.M.
        • Stern M.
        Hyperinsulinemia: the key feature of a cardiovascular and metabolic syndrome.
        Diabetologia. 1991; 34: 416

      Article info

      Publication history

      Accepted: March 9, 1993
      Received in revised form: February 26, 1993
      Received: November 6, 1992

      Identification

      DOI: https://doi.org/10.1016/0021-9150(93)90106-5

      Copyright

      © 1993 Published by Elsevier Inc.

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