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Abstract
The relationship between plasma lipoprotein(a) (Lp(a)) levels and other clinical/biochemical
variables was investigated in 1200 consecutive hyperlipidemic patients. Plasma Lp(a)
concentrations were measured by a sandwich-ELISA method, while the patients were either
on diet or diet plus lipid-lowering drugs; 38% of them had a plasma Lp(a) level >
30 mg/dl. The median plasma Lp(a) concentration and the frequency of Lp(a) > 30 mg/dl
were significantly lower in individuals with severe hypertriglyceridemia vs. hypercholesterolemics
(HC) or mixed hyperlipidemics (M-HLP), but similar to normolipidemic healthy controls.
Patients with isolated moderate hypertriglyceridemia had Lp(a) levels intermediate
between HC and M-HLP subjects. The in vitro addition of triglyceride-rich lipoproteins
to normotriglyceridemic plasma did not affect the Lp(a) measurement. Plasma Lp(a)
concentrations in the whole hyperlipidemic population correlated negatively with triglycerides
and positively with total cholesterol, HDL-cholesterol and age, being unrelated to
either body mass index or lipid-lowering treatment. In HC patients, the presence of
tendon xanthomas was associated with twofold higher Lp(a) levels. These findings argue
for a regulatory role of triglycerides on plasma Lp(a) levels in hyperlipidemic patients.
Keywords
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Article info
Publication history
Accepted:
March 18,
1993
Received in revised form:
March 15,
1993
Received:
July 13,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
