This paper is only available as a PDF. To read, Please Download here.
Abstract
The relationship between plasma lipoprotein(a) (Lp(a)) levels and other clinical/biochemical
variables was investigated in 1200 consecutive hyperlipidemic patients. Plasma Lp(a)
concentrations were measured by a sandwich-ELISA method, while the patients were either
on diet or diet plus lipid-lowering drugs; 38% of them had a plasma Lp(a) level >
30 mg/dl. The median plasma Lp(a) concentration and the frequency of Lp(a) > 30 mg/dl
were significantly lower in individuals with severe hypertriglyceridemia vs. hypercholesterolemics
(HC) or mixed hyperlipidemics (M-HLP), but similar to normolipidemic healthy controls.
Patients with isolated moderate hypertriglyceridemia had Lp(a) levels intermediate
between HC and M-HLP subjects. The in vitro addition of triglyceride-rich lipoproteins
to normotriglyceridemic plasma did not affect the Lp(a) measurement. Plasma Lp(a)
concentrations in the whole hyperlipidemic population correlated negatively with triglycerides
and positively with total cholesterol, HDL-cholesterol and age, being unrelated to
either body mass index or lipid-lowering treatment. In HC patients, the presence of
tendon xanthomas was associated with twofold higher Lp(a) levels. These findings argue
for a regulatory role of triglycerides on plasma Lp(a) levels in hyperlipidemic patients.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to AtherosclerosisAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The mysteries of lipoprotein(a).Science. 1989; 246: 904
- Lipoprotein(a) is not a metabolic product of other lipoproteins containing apolipoprotein B.Biochim. Biophys. Acta. 1979; 575: 63
- Studies on the role of specific cell surface receptors in the removal of lipoprotein(a) in man.J. Clin. Invest. 1983; 71: 1431
- HMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels.Circulation. 1989; 80: 1313
- Diverging effects of cholestyramine on apolipoprotein B and lipoprotein Lp(a).Atherosclerosis. 1982; 44: 61
- The association between serum Lp(a) concentration and angiographically assessed coronary atherosclerosis.Atherosclerosis. 1986; 62: 249
- Lp(a) lipoprotein and pre-beta lipoproteins in patients with coronary heart disease.Clin. Genet. 1974; 6: 230
- Lp(a) phenotypes, other lipoprotein parameters and family history of heart disease in middle-aged males.Clin. Genet. 1979; 16: 347
- Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary heart disease documented by angiography.Circulation. 1986; 74: 758
- Apolipoproteins(a), AI, and B and parental history in man with early onset ischaemic heart disease.Lancet. 1988; 1: 1070
- Serum Lp(a) level as a predictor of vein graft stenosis after coronary artery bypass surgery in patients.Circulation. 1988; 77: 1238
- A dominant role of lipoprotein(a) in the investigation and evaluation of parameters indicating the development of cervical atherosclerosis.Atherosclerosis. 1985; 58: 187
- Lipoprotein(a). A unique risk factor for atherothrombotic disease.Arteriosclerosis. 1990; 10: 672
- Genetics of quantitative Lp(a) lipoprotein trait. I. Relation of Lp(a) glycoprotein phenotypes to Lp(a) lipoprotein concentrations in plasma.Hum. Genet. 1988; 78: 41
- Genetics of the quantitative Lp(a) lipoprotein trait. II. Inheritance of Lp(a) phenotypes.Hum. Genet. 1988; 78: 47
- Defects in the low density lipoprotein receptor gene affect lipoprotein(a) levels: multiplicative interaction of two gene loci associated with premature atherosclerosis.in: 3rd Edn. Proc. Natl. Acad. Sci. USA. 86. 1989: 4171
- Levels of lipoprotein(a) decline with neomycin and niacin treatment.Atherosclerosis. 1985; 57: 293
- Report of the National Cholesterol Education Program Expert Panel on detection, evaluation and treatment of high blood cholesterol in adults.Arch. Intern. Med. 1988; 36: 36
- The hypertriglyceridemias: risk and management.Am. J. Cardiol. 1991; 68: 1A
- Role of diet in atherosclerosis.Atheroscler. Rev. 1980; 7: 157
- Quantitative determination of serum triglycerides by use of enzymes.Clin. Chem. 1973; 19: 476
- Enzymatische Bestimmung des Gesamt-Cholesterins im Serum.Z. Klin. Chem. Klin. Biochem. 1974; 12: 403
- Dextran sulfate precipitation procedure for quantitation of high density lipoproteins.Clin. Chem. 1982; 28: 1379
- Calculated values for low-density lipoprotein cholesterol in the assessment of lipid abnormalities and coronary disease risk.Clin. Chem. 1990; 36: 36
- Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.Clin. Chem. 1972; 18: 499
- Free and apo B-associated Lp(a)-specific protein in human serum.Clin. Chim. Acta. 1987; 164: 93
- Heterogeneity of human plasma lipoprotein(a).J. Biol. Chem. 1984; 259: 11470
- Evaluation of an enzyme immunoassay kit for the determination of lipoprotein(a).Clin. Chem. 1990; 36: 955a
- Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma.J. Clin. Invest. 1987; 80: 458
- Lipoprotein Lp(a) and the risk for myocardial infarction.Atherosclerosis. 1981; 38: 51
- The relationship of lipoprotein(a) to risk factors of coronary heart disease.J. Clin. Chem. Clin. Biochem. 1984; 22: 91
- Lipid transfer protein-catalized exchange of cholesteryl ester between high density lipoproteins and apo B-containing lipoproteins.J. Lipid Res. 1987; 28: 1053
- Solubility, immunochemical and lipoprotein binding properties of apo B-100-apo[a], the protein moiety of lipoprotein[a].J. Lipid Res. 1990; 31: 909
- Genetics of quantitative Lp(a) lipoprotein trait. III. Contribution of Lp(a) glycoprotein phenotypes to normal lipid variation.Hum. Genet. 1989; 82: 73
- Lp(a) levels in different types of dyslipidemia in the French population.Atherosclerosis. 1990; 85: 61
- Lack of effect of probucol on serum lipoprotein(a) levels.Atherosclerosis. 1989; 79: 267
- Fluctuations of plasma lipoprotein(a) concentrations during pregnancy and post partum.Metabolism. 1986; 35: 333
- Lipoprotein(a) and apoprotein changes after cardiac transplantation.J. Am. Coll. Cardiol. 1991; 18: 926
- Lp(a) and plasma tri glyceride-rich lipoproteins.Klin. Wochenschr. 1990; 68: 117
- Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein(a) and that cause lipid accumulation in macrophages.J. Clin. Invest. 1986; 77: 622
- Interrelation of Lp(a) with plasma triglycerides.Atherosclerosis Rev. 1991; 22: 131
- Lipoprotein Lp(a) in homozygous familial hypercholesterolemia: density profile, particle heterogeneity and apolipoprotein(a) phenotype.Atherosclerosis. 1991; 31: 69
- Lipoprotein (a). Heterogeneity and biological relevance.J. Clin. Invest. 1990; 85: 1709
- Plasma Lp(a) patterns after triglyceride infusion.Atherosclerosis Rev. 1991; 22: 137
- Relationship between apo(a) isoforms and Lp(a) density in subjects with different apo(a) phenotype: a study before and after a fatty meal.J. Lipid Res. 1991; 32: 679
Morrisett, J., Gaubatz, J., Nava, M., Guyton, J., Hoffman, A., Opekun, A. and Hachey, D., Metabolism of apo(a) and apo-B-100 in human lipoprotein(a). XI International Symposium on Drugs Affecting Lipid Metabolism, Abs. Book, p. 112.
- Influence of dietary fish oils on plasma Lp(a) levels.Thromb. Res. 1990; 58: 667
Article info
Publication history
Accepted:
March 18,
1993
Received in revised form:
March 15,
1993
Received:
July 13,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.