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Abstract
Six healthy male volunteers were served 4 strictly controlled isoenergetic diets differing
in fat (20% or 50% of energy) and fiber contents (2 or 4 g/MJ) for periods of 2 days.
The diets were served in random order with at least 5 days separating each diet period.
Blood samples for determination of factor VII clotting activity using human (FVIIc)
and bovine thromboplastin (MIN), and for assessment of factor VII antigen (FVIIag),
tissue-plasminogen activator (t-PA) antigen, plasminogen activator inhibitor-1 (PAI-1)
antigen, PAI activity, t-PA and euglobulin fibrinolytic activity, and triglyceride
and insulin levels were collected regularly on the second day of each diet period.
The high-fat diets resulted in significantly increased postprandial MIN levels (peak
values: 131% vs. 95%, P < 0.01), and higher postprandial FVIIbt/FVIIag ratios (peak values: 1.42 vs. 1.16,
P < 0.01) compared with the low-fat diets. Fibrinolytic variables were not affected
by the dietary changes and consistently showed characteristic U-shaped (t-PA and PAI-1
antigen, PAI activity), or inverted U-shaped (t-PA and euglobulin fibrinolytic activity)
circadian patterns with troughs and peaks, respectively, at 17:30-21:30 h. The dietary
fiber content had no significant influence on any of the measured variables. Our findings
indicate that high-fat diets may increase blood thrombogenicity by virtue of augmented
postprandial activation of factor VII.
Keywords
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Article info
Publication history
Accepted:
March 23,
1993
Received in revised form:
March 11,
1993
Received:
November 12,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.