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Abstract
The regeneration of rat aorta intima and medial layer was examined after extensive
freeze injury that caused the death of both endothelial and smooth muscle cells. After
1 month complete re-endothelialization of the denuded area was observed. In parallel,
myointimal thickening was formed by the smooth muscle cells (SMC) from the uninjured
edges and its thickness increased with time. The SMC of myointimal thickening were
stellate in the upper part and elongated near the internal elastic lamina. No regenerative
response was seen in the medial layer, consisting only of elastic and collagen fibers,
and its thickness was reduced during regeneration. These results show that the regenerative
response of medial SMC to extensive freeze injury proceeds in the form of intimal
thickening.
Keywords
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Article info
Publication history
Accepted:
April 28,
1993
Received in revised form:
April 7,
1993
Received:
November 26,
1992
Identification
Copyright
© 1993 Published by Elsevier Inc.
