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Research paper| Volume 108, ISSUE 2, P149-157, August 1994

Decreased plasma levels of lipoprotein(a) in patients with hypertriglyceridemia

DOI:https://doi.org/10.1016/0021-9150(94)90109-0
Decreased plasma levels of lipoprotein(a) in patients with hypertriglyceridemia
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      Abstract

      Lipoprotein(a) (Lp(a)) is an atherogenic lipoprotein which is similar in structure to, but metabolically distinct from, LDL. Factors modulating plasma Lp(a) concentrations are poorly understood. To investigate the possible interaction of Lp(a) with triglycerides, we determined the apo(a) phenotype, Lp(a) concentration, and distribution of Lp(a) in a group of patients with triglycerides > 400 mg/dl (n = 60) compared with a control group (n = 128). Lp(a) concentrations were significantly lower in hypertriglyceridemic patients (mean ± S.E., 13 ± 4 mg/dl; median, 6 mg/dl; 25/75 percentile, 2–13 mg/dl) as compared with the controls (mean, 22 ± 2 mg/dl; median, 10 mg/dl; 25/75 percentile, 7–30 mg/dl.) Plasma Lp(a) concentrations in the hypertriglyceridemic patients correlated negatively with triglyceride levels (r = -0.69, P = 0.03). The difference in Lp(a) levels between patients and controls was maintained when subjects were stratified by apo(a) phenotype and type of hyperlipidemia. After subdividing the hypertriglyceridemic patients into one group with apo(a) isoforms ≤ S2 and one group with apo(a) isoforms Math EqS3, we found that the differences in plasma Lp(a) concentrations between patients and controls were more pronounced in the group with the lower molecular weight apo(a) isoforms. These data indicate that hypertriglyceridemia is associated with lower plasma Lp(a) concentrations and suggest that increased levels of triglyceride-rich lipoproteins may influence the metabolism of Lp(a).

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      Article info

      Publication history

      Accepted: March 31, 1994
      Received in revised form: March 8, 1994
      Received: November 9, 1993

      Identification

      DOI: https://doi.org/10.1016/0021-9150(94)90109-0

      Copyright

      © 1994 Published by Elsevier Inc.

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