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Abstract
Plasma factor VII activity (FVIIc) is one of the independent risk factors of coronary
artery disease (CAD) and is controlled by both genetic and environmental factors.
South Asians including Indians have one of the highest prevalence and mortality rates
from CAD while the Chinese have a much lower risk. Generally accepted risk factors
cannot explain the high mortality from CAD in Indians. We examined two hundred and
seventy seven Chinese (124 m, 153 f); and 216 healthy Indian (150 m, 66 f) adults
for serum lipids; plasma FVIIc and FVIIag levels in order to examine racial variations
of these and their correlates in these two populations. Both Indian men and women
had significantly higher FVIIc levels (12% and 11%, respectively) than the Chinese
even after adjustments of age, BMI and lipids (P < 0.01). In contrast, Indians had significantly lower plasma FVIIag levels than Chinese
(8% and 9%, respectively in men and women; P < 0.01). Multiple linear regression analysis shows a strong correlation of FVIIc
with serum triglycerides accounting for 4–8% of the total variability of FVIIc in
different groups. Further, there was a stronger correlation between FVIIc and FVIIag
in Indians than that in the Chinese (0.43 vs. 25) suggesting a greater activation
resulting in higher FVIIc in Indians inspite of lower FVIIag levels. The higher FVIIc
and stronger activation by triglycerides observed in this study partly explain the
higher risk of CAD in Indians.
Keywords
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Article info
Publication history
Accepted:
February 28,
1995
Received in revised form:
February 21,
1995
Received:
September 12,
1994
Identification
Copyright
© 1995 Published by Elsevier Inc.
